Mixed-mode ion-exchange materials, including silica-based, polymer-based and other supports, have been applied in sample treatment with different techniques, mainly solid-phase extraction, but also other microextraction techniques such as solid-phase microextraction, stir bar sorptive extraction and microextraction by packed sorbent. These materials are widespread because they conveniently combine capacity (through the reversed-phase interactions in the material backbone) and selectivity (through the specific ion-exchange interactions). This review provides an overview of the advances and applications of mixed-mode ion-exchange materials for the extraction of organic compounds from complex matrices in environmental, food and biological samples. We summarise the different approaches used to prepare these materials and discuss the extraction protocols applied and the types of compounds and samples analysed based on different selected examples.

中文翻译：

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混合模式 ION-EXCHANGE 材料在有机化合物萃取中的概述

混合模式离子交换材料，包括硅胶基、聚合物基和其他载体，已应用于不同技术的样品处理，主要是固相萃取，也有其他微萃取技术，如固相微萃取、搅拌棒通过填充吸附剂进行吸附萃取和微萃取。这些材料之所以广泛使用，是因为它们方便地将容量（通过材料骨架中的反相相互作用）和选择性（通过特定的离子交换相互作用）结合在一起。本综述概述了混合模式离子交换材料在从环境、食品和生物样品中的复杂基质中提取有机化合物的进展和应用。