BACKGROUND Serum glucose and potassium ratio (GPR) was recently found to be related to outcome of aneurysmal subarachnoid hemorrhage. This retrospectively study was to investigate the association of serum GPR with mortality in severe traumatic brain injury (sTBI). METHODS Clinical data were retrospectively reviewed of isolated sTBI patients admitted within 12 h after trauma between January 2014 and January 2019. We analyzed relationships between admission serum GPR and post-traumatic 30-day mortality in addition to admission Glasgow coma scale (GCS) scores. Discriminative ability was evaluated using area under receiver operating characteristic curve (AUC). RESULTS A total of 146 patients, of whom 37 (25.3%) died within 30 days following trauma, were included. Admission serum GPR emerged as an independent predictor for 30-day mortality (odds ratio, 5.256; 95% confidence interval (CI), 1.111-14.856) and overall survival (hazard ratio, 4.822; 95% CI, 1.157-12.870), with an AUC of 0.777 (95% CI, 0.693-0.835), which was equivalent to that of GCS scores (AUC, 0.831; 95% CI, 0.760-0.888; P = 0.179). There was a significant correlation between admission serum GPR and GCS scores (r2 = 0.293). CONCLUSIONS Serum GPR in cases of sTBI is substantially associated with trauma severity and 30-day mortality. Therefore, the potential value of serum GPR for predicting short-term mortality of sTBI patients is favorable.

中文翻译：

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血清葡萄糖和钾的比率可作为严重颅脑外伤患者30天死亡的预测指标。

背景技术最近发现血清葡萄糖和钾的比率（GPR）与动脉瘤性蛛网膜下腔出血的结果有关。这项回顾性研究旨在研究血清GPR与严重外伤性脑损伤（sTBI）的死亡率之间的关系。方法回顾性分析2014年1月至2019年1月在创伤后12小时内入院的sTBI患者的临床资料。我们分析了入院血清GPR与创伤后30天死亡率之间的关系，以及入院格拉斯哥昏迷量表（GCS）评分。使用接收器工作特性曲线（AUC）下的面积评估判别能力。结果总共包括146名患者，其中37名（25.3％）在创伤后30天内死亡。入院血清GPR可以作为30天死亡率（赔率，5.256; 95％置信区间（CI），1.111-14.856）和总生存期（危险比，4.822; 95％CI，1.157-12.870）的独立预测因子， AUC为0.777（95％CI，0.693-0.835），与GCS得分（AUC，0.831； 95％CI，0.760-0.888； P = 0.179）相当。入院血清GPR与GCS评分之间存在显着相关性（r2 = 0.293）。结论sTBI患者的血清GPR与创伤的严重程度和30天的死亡率密切相关。因此，血清GPR预测sTBI患者短期死亡率的潜在价值是有利的。这与GCS分数相当（AUC为0.831； 95％CI为0.760-0.888； P = 0.179）。入院血清GPR与GCS评分之间存在显着相关性（r2 = 0.293）。结论sTBI患者的血清GPR与创伤严重程度和30天死亡率基本相关。因此，血清GPR预测sTBI患者短期死亡率的潜在价值是有利的。这与GCS分数相当（AUC为0.831； 95％CI为0.760-0.888； P = 0.179）。入院血清GPR与GCS评分之间存在显着相关性（r2 = 0.293）。结论sTBI患者的血清GPR与创伤严重程度和30天死亡率基本相关。因此，血清GPR预测sTBI患者短期死亡率的潜在价值是有利的。