The aim of this study was to detect evidence for signatures of recent selection in the Jinhua pig genome. These results can be useful to better understand the regions under selection in Jinhua pigs and might shed some lights on groups of genes that control production traits. In the present study, we performed extended haplotype homozygosity (EHH) tests to identify significant core regions in 202 Jinhua pigs. A total of 26 161 core regions spanning 636.42 Mb were identified, which occupied approximately 28% of the genome across all autosomes, and 1 158 significant (P<0.01) core haplotypes were selected. Genes in these regions were related to several economically important traits, including meat quality, reproduction, immune responses and exterior traits. A panel of genes including ssc-mir-365-2, KDM8, RABEP2, GSG1L, RHEB, RPH3AL and a signal pathway of PI3K-Akt were detected with the most extreme P-values. The findings in our study could draw a comparatively genome-wide map of selection signature in the pig genome, and also help to detect functional candidate genes under positive selection for further genetic and breeding research in Jinhua and other pigs.

这项研究的目的是寻找金华猪基因组中最近选择的特征的证据。这些结果可能有助于更好地了解金华猪的选择区域，并可能有助于阐明控制生产性状的基因组。在本研究中，我们进行了扩展的单倍型纯合性（EHH）测试，以鉴定202只金华猪的重要核心区域。共鉴定出26 161个核心区域，跨越636.42 Mb，占据了所有常染色体的约28％的基​​因组，并选择了1 158个重要的（P <0.01）核心单倍型。这些地区的基因与几个重要的经济性状有关，包括肉质，繁殖，免疫反应和外在性状。一组基因包括检测到ssc-mir-365-2，KDM8，RABEP2，GSG1L，RHEB，RPH3AL和PI3K-Akt的信号通路时，P值最大。我们研究中的发现可以绘制出猪基因组中选择签名的全基因组图谱，也有助于检测正选择下的功能候选基因，以用于金华和其他猪的进一步遗传和育种研究。