Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8+ T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment.

中文翻译：

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IL-9和IL-9产生细胞对肿瘤具有免疫力。

白介素（IL）-9属于IL-2Rγc链家族，是一种多功能的细胞因子，可以调节多种细胞的功能。最初被确定为T细胞和肥大细胞的生长因子。在以前的研究中，IL-9主要参与过敏性疾病，自身免疫性疾病和寄生虫感染的发展。最近，IL-9，作为癌症发展中的双刃剑，已引起广泛关注。自从T-helper 9（Th9）细胞来源的IL-9被证实在实体瘤中发挥强大的抗肿瘤作用以来，越来越多的研究人员开始关注IL-9倾斜的CD8 + T（Tc9）的作用。细胞，肥大细胞和Vδ2T细胞来源的IL-9在肿瘤免疫中的作用。这里，