Impaired sleep is common in menopausal women. The aim was to examine associations between uses of systemic menopausal hormone therapy (MHT) and sleep disturbance in a large population sample. Female participants aged 45 to 75 years were selected from the Norwegian Health Study in Nord-Trøndelag (HUNT3, 2006–2008) (N = 13,060). Data were linked to the Norwegian Prescription Database, identifying use of prescribed MHT and use of sleep medication. Data were analyzed using multiple linear regression. In total, 996 women used systemic MHT (7.6%), with the highest prevalence of 10.3% among women 55 to 64 years of age. Despite high reports of frequent nocturnal awakening (24.7%) and high reports of hot flashes, use of MHT was low in this large population based survey. Although MHT use was associated with more sleep disturbance in unadjusted analyses, the association was not significant after adjusting for relevant covariates. Using sleep medication, reporting poor health, tobacco and alcohol use, doing daily exercise, having higher levels of anxiety, and being less satisfied with life were factors showing the strongest associations with sleep disturbance. The lack of association between MHT and sleep disturbance suggests that other factors, such as self-perceived good health, a healthy lifestyle and anxiety/depression, are more relevant to sleep than MHT.

中文翻译：

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更年期激素治疗与绝经过渡期和绝经后女性睡眠障碍之间的关联：来自挪威处方数据库和 HUNT 研究的数据。

睡眠受损在更年期女性中很常见。目的是在大量人群样本中研究全身性更年期激素治疗 (MHT) 与睡眠障碍之间的关联。年龄 45 至 75 岁的女性参与者选自 Nord-Trøndelag 的挪威健康研究（HUNT3，2006-2008）（N = 13,060）。数据与挪威处方数据库相关联，确定处方 MHT 的使用情况和安眠药物的使用情况。使用多元线性回归分析数据。总共有 996 名女性使用了全身 MHT（7.6%），其中 55 至 64 岁女性的患病率最高，为 10.3%。尽管夜间频繁醒来 (24.7%) 和潮热的报道较多，但在这项基于人口的大型调查中，MHT 的使用率较低。尽管在未经调整的分析中，MHT 的使用与更多的睡眠障碍相关，但在调整相关协变量后，这种关联并不显着。使用安眠药、报告健康状况不佳、吸烟和饮酒、每天锻炼、焦虑程度较高以及对生活不太满意是与睡眠障碍最密切相关的因素。MHT 和睡眠障碍之间缺乏关联表明，其他因素，例如自我感觉良好的健康状况、健康的生活方式和焦虑/抑郁，比 MHT 与睡眠更相关。