Blood flow in the corpus luteum is associated with luteal function. However, the impact of luteal blood flow on methotrexate (MTX) treatment in women with unruptured tubal pregnancy has not been reported. The aim of the present study was to observe the impact of luteal blood flow on the therapeutic effect of MTX in women with unruptured tubal pregnancy. A prospective observational study recruited 129 women with unruptured tubal pregnancy in the First Affiliated Hospital of Xi’an Jiaotong University from September 2016 to June 2018. One hundred and fifteen women were treated successfully with MTX, and women were divided into 2 groups according to luteal blood flow: the poor luteal blood flow group and the abundant luteal blood flow group. The therapeutic effects were compared between the two groups. Women in the abundant luteal blood flow group had a significantly higher serum β-human chorionic gonadotropin (β-hCG) level 4 days, 1 week and 2 weeks after MTX treatment compared with women in the poor luteal blood flow group (P < 0.05). The average diameter of the ectopic mass 1 week, 2 weeks and 3 weeks after MTX treatment in women with abundant luteal blood flow was significantly larger (P < 0.05), and the time of serum β-hCG clearance and ectopic mass disappearance were significantly longer compared with those in women in the poor luteal blood flow group (P < 0.05). Luteal blood flow might be a predictive factor for MTX treatment outcomes in women with unruptured tubal pregnancy, and those with abundant luteal blood flow need a longer recovery time.

中文翻译：

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黄体血流量作为未破裂输卵管妊娠妇女甲氨蝶呤治疗结果的预测因素

黄体中的血流与黄体功能有关。但是，尚未报道黄体血流对未破裂输卵管妊娠妇女甲氨蝶呤（MTX）治疗的影响。本研究的目的是观察黄体血流量对未破裂输卵管妊娠妇女MTX治疗效果的影响。一项前瞻性观察性研究于2016年9月至2018年6月在西安交通大学第一附属医院招募了129名输卵管妊娠未破裂的女性。115例女性成功接受MTX治疗，根据黄体分为两组血流：黄体血流不良组和黄体血流丰富组。比较两组之间的治疗效果。黄体血流量丰富组的妇女在MTX治疗后4天，1周和2周的血清β-人绒毛膜促性腺激素（β-hCG）水平显着高于黄体血流量不良组的妇女（P <0.05） 。黄体血流量丰富的妇女MTX治疗后1周，2周和3周的异位肿块平均直径明显更大（P <0.05），血清β-hCG清除时间和异位肿块消失的时间明显更长与黄体血液流动不良的女性相比（P <0.05）。黄体血流量可能是未破裂输卵管妊娠妇女MTX治疗结果的预测因素，而黄体血流量丰富的女性需要更长的恢复时间。与黄体血流不畅组的女性相比，MTX治疗后1周和2周的女性（P <0.05）。黄体血流量丰富的妇女MTX治疗后1周，2周和3周的异位肿块平均直径明显更大（P <0.05），血清β-hCG清除时间和异位肿块消失的时间明显更长与黄体血液流动不良的女性相比（P <0.05）。黄体血流量可能是未破裂输卵管妊娠妇女MTX治疗结果的预测因素，而黄体血流量丰富的女性需要更长的恢复时间。与黄体血流不畅组的女性相比，MTX治疗后1周和2周的女性（P <0.05）。黄体血流量丰富的妇女MTX治疗1周，2周和3周后异位肿块的平均直径明显更大（P <0.05），血清β-hCG清除时间和异位肿块消失的时间明显更长与黄体血液流动不良的女性相比（P <0.05）。黄体血流量可能是未破裂输卵管妊娠妇女MTX治疗结果的预测因素，而黄体血流量丰富的女性需要更长的恢复时间。黄体血流量充足的女性，MTX治疗后2周和3周的女性明显更大（P <0.05），血清β-hCG清除和异位肿块消失的时间明显更长。流动组（P <0.05）。黄体血流量可能是未破裂输卵管妊娠妇女MTX治疗结果的预测因素，而黄体血流量丰富的女性需要更长的恢复时间。黄体血流量充足的女性，MTX治疗后2周和3周的女性明显更大（P <0.05），血清β-hCG清除和异位肿块消失的时间明显更长。流动组（P <0.05）。黄体血流量可能是未破裂输卵管妊娠妇女MTX治疗结果的预测因素，而黄体血流量丰富的女性需要更长的恢复时间。