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Risk factors during pregnancy and delivery for the development of Perthes’ disease, a nationwide Swedish study of 2.1 million individuals
BMC Pregnancy and Childbirth ( IF 3.1 ) Pub Date : 2020-03-30 , DOI: 10.1186/s12884-020-2849-7
Maria Lindblad , Ann Josefsson , Marie Bladh , Gunilla Sydsjö , Torsten Johansson

To ascertain or disprove a correlation between suboptimal birth characteristics, breech position at delivery and development of Perthes’ disease. Study material was collected from nationwide registers regarding diagnoses, birth statistics and delivery data. As study population were included children with a diagnosis code for Perthes’ disease who were alive and living in Sweden at age 13. Children with missing birth statistics were excluded. All children with no Perthes’ disease diagnosis were used as control group. Both single and multiple logistical regression analyses were used to calculate OR for the included characteristics. Children in breech position had a higher risk for developing Perthes’ disease. Children with Perthes’ disease had also a higher probability of having been born pre-term, very pre-term or post-term. Lower than normal birth weight and a lower Apgar-score were also associated with Perthes’ disease. There is a correlation between breech birth and development of Perthes’ disease. There is also correlation to suboptimal birth characteristics. Despite our findings this should not be used for screening of Perthes’ disease as the percentage of children who actually develop it is very low. Also, as of yet there is no possibility to diagnose Perthes’ disease before the presence of skeletal changes. Our findings could be important in finding the cause of Perthes’ disease and therefore developing better diagnostics, treatment and prevention.

中文翻译:

瑞典全国210万人的研究表明,怀孕和分娩期间发生Perthes病的危险因素

为了确定或证明次优出生特征,分娩时臀位和Perthes病发展之间的相关性。研究材料是从全国性的登记处收集的,有关诊断,出生统计和分娩数据。由于研究人群包括在瑞典存活并生活在13岁的,具有Perthes病诊断码的儿童,因此排除了出生统计缺失的儿童。所有未诊断出Perthes病的儿童均作为对照组。单个和多个逻辑回归分析都用于计算所包含特征的OR。处于臀位的儿童患Perthes病的风险更高。患有Perthes病的儿童早产,早产或早产的可能性也更高。低于正常出生体重和较低的Apgar得分也与Perthes病相关。臀位出生与Perthes病的发展之间存在相关性。次优出生特征也有相关性。尽管有我们的发现,但不应将其用于筛查Perthes病,因为实际患该病的儿童所占的比例非常低。同样,到目前为止,还没有在骨骼变化之前就诊断出珀斯氏病的可能性。我们的发现对于寻找Perthes病的病因并因此开发更好的诊断,治疗和预防方法可能很重要。尽管有我们的发现,但不应将其用于筛查Perthes病,因为实际患该病的儿童所占的比例非常低。同样,到目前为止,还没有在骨骼变化之前就诊断出珀斯氏病的可能性。我们的发现对于寻找Perthes病的病因并因此开发更好的诊断,治疗和预防方法可能很重要。尽管有我们的发现,但不应将其用于筛查Perthes病,因为实际患该病的儿童比例非常低。同样,到目前为止,还没有在骨骼变化之前就诊断出珀斯氏病的可能性。我们的发现对于寻找Perthes病的病因并因此开发更好的诊断,治疗和预防方法可能很重要。
更新日期:2020-04-22
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