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The independent indicators for differentiating renal cell carcinoma from renal angiomyolipoma by contrast-enhanced ultrasound.
BMC Medical Imaging ( IF 2.7 ) Pub Date : 2020-03-30 , DOI: 10.1186/s12880-020-00436-9
Hongli Cao 1, 2 , Liang Fang 1, 2 , Lin Chen 1, 2 , Jia Zhan 1, 2 , Xuehong Diao 1, 2 , Yingchun Liu 1, 2 , Chen Lu 2, 3 , Zhengwang Zhang 2, 4 , Yue Chen 1, 2
Affiliation  

The value of contrast-enhanced ultrasound (CEUS) in differentiating between renal cell carcinoma (RCC) and angiomyolipoma (AML) was analyzed. The purpose of this study was to identify the independent indicators of CEUS for predicting RCC. A total of 172 renal tumors (150 RCCs, 22 AMLs) in 165 patients underwent conventional ultrasound (CUS) and CEUS examinations before radical or partial nephrectomy, and the features on CUS and CEUS were analyzed. There were significant differences in echogenicity, blood flow signals in color Doppler flow imaging (CDFI), peak intensity, homogeneity of enhancement, wash in, wash out, and perilesional rim-like enhancement between RCC and AML (P < 0.05 for all). Multivariate analysis indicated that perilesional rim-like enhancement (P = 0.035, odds ratio [OR] = 9.907, 95% confidence interval [CI]: 1.169–83.971) and fast wash out (P = 0.001, OR = 9.755, 95%[CI]: 2.497–38.115) were independent indicators for predicting RCC. The area under the receiver operating characteristic (ROC) curve (AUC) for perilesional rim-like enhancement was 0.838 (95% CI: 0.774–0.890) with 76.7% sensitivity and 90.9% specificity, while the AUC of fast wash out was 0.833 (95% CI:0.768–0.885) with 74.7% sensitivity and 81.8% specificity. This study indicated that CEUS has value in differentiating RCC and AML. Present perilesional rim-like enhancement and fast wash out may be important indicators for predicting RCC.

中文翻译:

超声造影鉴别肾细胞癌与肾血管平滑肌脂肪瘤的独立指标。

分析了超声造影(CEUS)在区分肾细胞癌(RCC)和血管平滑肌脂肪瘤(AML)中的价值。这项研究的目的是确定CEUS预测RCC的独立指标。165例患者中总共172例肾肿瘤(150例RCC,22例AML)在进行根治性或部分肾切除术之前接受了常规超声(CUS)和CEUS检查,并分析了CUS和CEUS的特征。RCC和AML之间在回声性,彩色多普勒血流成像(CDFI)中的血流信号,峰值强度,增强的均一性,冲洗,冲洗和病灶周围边缘样增强方面存在显着差异(所有P均<0.05)。多变量分析表明,病灶周围边缘样增强(P = 0.035,优势比[OR] = 9.907,95%置信区间[CI]:1.169-83。971)和快速洗脱(P = 0.001,OR = 9.755,95%[CI]:2.497–38.115)是预测RCC的独立指标。病灶周围边缘样增强的接受者工作特征(ROC)曲线下面积(AUC)为0.838(95%CI:0.774-0.890),灵敏度为76.7%,特异度为90.9%,而快速洗脱的AUC为0.833( 95%CI:0.768–0.885),灵敏度为74.7%,特异性为81.8%。这项研究表明,CEUS在区分RCC和AML方面具有价值。目前病灶周围边缘样增强和快速冲洗可能是预测RCC的重要指标。敏感性为7%,特异性为90.9%,而快速洗脱的AUC为0.833(95%CI:0.768–0.885),敏感性为74.7%,特异性为81.8%。这项研究表明,CEUS在区分RCC和AML方面具有价值。目前病灶周围边缘样增强和快速冲洗可能是预测RCC的重要指标。敏感性为7%,特异性为90.9%,而快速洗脱的AUC为0.833(95%CI:0.768–0.885),敏感性为74.7%,特异性为81.8%。这项研究表明,CEUS在区分RCC和AML方面具有价值。目前病灶周围边缘样增强和快速冲洗可能是预测RCC的重要指标。
更新日期:2020-04-22
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