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Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis.
BMC Medical Genetics ( IF 2.023 ) Pub Date : 2020-03-30 , DOI: 10.1186/s12881-020-01006-0
Xiaochun Jin 1 , Yueyuan Wu 2 , Shuzhou Yin 1 , Xu Chen 2 , Youtao Zhang 2
Affiliation  

BACKGROUND Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (- 1082 G/A, - 819 C/T, - 592C/A) and IL-6 -174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility. METHODS Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used. RESULTS The significant associations were only found in Asian population of - 819 loci under three genetic models as follows: (Allele model: OR = 0.60, 95%CI = 0.44-0.82, P = 0.001), (homozygote comparison: OR = 0.24, 95%CI = 0.09-0.62, P = 0.003), (recessive genetic model: OR = 0.22, 95%CI = 0.05-0.91, P = 0.036). CONCLUSION In conclusion, IL-10 - 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10 -1082 G/A, 592 loci and IL-6 -174 G/C polymorphism are not associated with Brucellosis risk.

中文翻译:

IL-10和IL-6多态性与布鲁氏菌病易感性之间的关联:一项荟萃分析。

背景技术布鲁氏菌病是一种非常正常的人畜共患病感染,由与布鲁氏菌或其产品感染的动物立即接触引起。IL-10(-1082 G / A,-819 C / T,-592C / A)和IL-6 -174 G / C多态性与IL-10和IL-6产生密切相关,这导致布鲁氏菌病的发病机理和发展。迄今为止,已发表文献的结果是有争议的。现在,我们在不同种族的人群中进行荟萃分析,以更精确地估计上述多态性与布鲁氏菌病的易感性。方法通过提取病例和对照组的基因分型频率,纳入OR和相应的95%CI以评估关联强度。应用基于χ2检验的Q统计量和I2统计量。如果没有明显的异质性,将应用固定效果模型。如果不是这样,将使用随机效应模型。结果在以下三种遗传模型下,仅在-819个基因座的亚洲人群中发现了显着相关性:(等位基因模型:OR = 0.60,95%CI = 0.44-0.82,P = 0.001),(纯合子比较:OR = 0.24, 95%CI = 0.09-0.62,P = 0.003)(隐性遗传模型:OR = 0.22,95%CI = 0.05-0.91,P = 0.036)。结论综上所述,IL-10-819位点多态性对高加索人群没有影响,但可能与亚洲人群的降低风险有关。IL-10 -1082 G / A,592个基因座和IL-6 -174 G / C多态性与布鲁氏菌病风险无关。(等位基因模型:OR = 0.60,95%CI = 0.44-0.82,P = 0.001),(纯合子比较:OR = 0.24,95%CI = 0.09-0.62,P = 0.003),(隐性遗传模型:OR = 0.22 ,95%CI = 0.05-0.91,P = 0.036)。结论综上所述,IL-10-819位点多态性对高加索人群没有影响,但可能与亚洲人群的降低风险有关。IL-10 -1082 G / A,592个基因座和IL-6 -174 G / C多态性与布鲁氏菌病风险无关。(等位基因模型:OR = 0.60,95%CI = 0.44-0.82,P = 0.001),(纯合子比较:OR = 0.24,95%CI = 0.09-0.62,P = 0.003),(隐性遗传模型:OR = 0.22 ,95%CI = 0.05-0.91,P = 0.036)。结论综上所述,IL-10-819位点多态性对高加索人群没有影响,但可能与亚洲人群的降低风险有关。IL-10 -1082 G / A,592个基因座和IL-6 -174 G / C多态性与布鲁氏菌病风险无关。
更新日期:2020-04-22
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