Contact lens is a major risk factor for microbial keratitis among contact lens wearers. Chemical strategies that can prevent microbial adhesion and biofilm formation are required to improve a wearer’s hygiene and safety. Taking advantage of the material-independent properties of a polydopamine (pDA) coating, we investigated the role of covalent/noncovalent interactions of the antimicrobials and pDA in conferring long-term antimicrobial activities. The developed antimicrobial contact lenses not only retain their antibacterial efficiency against different bacterial strains for 2 weeks but also inhibit microbial adhesion and biofilm formation on the lens surfaces. The designed antimicrobial coatings were found to be safe for ocular cell lines. Moreover, the antimicrobial coatings did not affect the functional and surface properties of coated contact lenses. This methodology can be used to protect the contact lenses from microbial contamination for prolonged periods and has the potential to be extended for designing antimicrobial coatings for other medical devices as well.

中文翻译：

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贻贝启发的耐用抗菌隐形眼镜：抗菌素的共价和非共价结合作用

隐形眼镜是戴隐形眼镜者中微生物角膜炎的主要危险因素。需要化学方法来防止微生物的粘附和生物膜的形成，以改善佩戴者的卫生和安全性。利用聚多巴胺（pDA）涂层的不依赖材料的特性，我们研究了抗菌剂和pDA的共价/非共价相互作用在赋予长期抗菌活性方面的作用。研发的抗菌隐形眼镜不仅可以保持其对不同细菌菌株的抗菌效果达2周，而且还可以抑制眼镜表面上的微生物粘附和生物膜形成。发现设计的抗微生物涂层对于眼细胞系是安全的。此外，抗菌涂层不会影响镀膜隐形眼镜的功能和表面性能。这种方法可用于长时间保护隐形眼镜免受微生物污染，并有可能扩展设计用于其他医疗设备的抗菌涂层。