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Synthesis and Characterization of Zwitterionic Polymer Brush Functionalized Hydrogels with Ionic Responsive Coefficient of Friction.
Langmuir ( IF 3.9 ) Pub Date : 2020-04-03 , DOI: 10.1021/acs.langmuir.9b03566
Allen O Osaheni 1, 2 , Ariel Ash-Shakoor 1, 3 , Ivan Gitsov 1, 4 , Patrick T Mather 5 , Michelle M Blum 1, 2
Affiliation  

Freeze–thaw poly(vinyl alcohol) hydrogels (PVA-H) offer great potential for several biomedical applications due to their biomimetic mechanical properties and biocompatibility. Despite these advantages, the use of PVA-H for load bearing applications has been limited due to poor performance in boundary lubrication compared to natural tissue such as articular cartilage. Recently, zwitterionic polymer brushes have been shown to act as effective boundary lubricants on rigid substrates; however, to the best of our knowledge, the synergistic effects of zwitterionic brushes coupled with the biomimetic fluid load support exhibited by hydrogels have not been reported. We report here on our investigation involving the synthesis and characterization of two unique types of polymer brush functionalized PVA hydrogels. The zwitterionic polymers that were compared contained either [2-(methacryloyloxy)ethyl]dimethyl-3-sulfopropylammonium hydroxide, PMEDSAH, or 2-methacryloyloxyethylphosphorylcholine, PMPC, repeating units. Both hydrogels coated with zwitterionic polymers were found to be cytocompatible. We report further on micrometer-scale surface properties via water contact angle goniometry, surface roughness measurements, and scanning electron microscopy. Finally, the impact of brush functionalization on the mechanics of the tribologically enhanced gels is reported with comparison to natural articular cartilage within the context of Hertzian contact theory.

中文翻译:

具有离子响应摩擦系数的两性离子聚合物刷功能化水凝胶的合成与表征。

冻融聚乙烯醇水凝胶(PVA-H)具有仿生机械性能和生物相容性,因此在多种生物医学应用中具有巨大潜力。尽管具有这些优点,但由于与天然组织(如关节软骨)相比边界润滑性能较差,PVA-H在承重应用中的使用受到了限制。近来,两性离子聚合物刷已显示出在刚性基材上的有效边界润滑剂的作用。然而,据我们所知,两性离子刷与水凝胶所表现出的仿生流体负载支持的协同作用尚未见报道。我们在这里报告我们的调查,涉及两种独特类型的聚合物刷功能化PVA水凝胶的合成和表征。比较的两性离子聚合物包含[2-(甲基丙烯酰氧基)乙基]二甲基-3-磺丙基丙基氢氧化铵,PMEDSAH,或2-甲基丙烯酰氧基乙基磷酰胆碱,PMPC,重复单元。发现两种涂有两性离子聚合物的水凝胶都具有细胞相容性。我们通过水接触角测角法,表面粗糙度测量和扫描电子显微镜进一步报告了微米级表面性能。最后,在赫兹接触理论的背景下,与天然关节软骨相比,报道了刷子功能化对摩擦学增强凝胶的力学的影响。发现两种涂有两性离子聚合物的水凝胶都具有细胞相容性。我们通过水接触角测角法,表面粗糙度测量和扫描电子显微镜进一步报告了微米级表面性能。最后,在赫兹接触理论的背景下,与天然关节软骨相比,报道了刷子功能化对摩擦学增强凝胶的力学的影响。发现两种涂有两性离子聚合物的水凝胶都具有细胞相容性。我们通过水接触角测角法,表面粗糙度测量和扫描电子显微镜进一步报告了微米级表面性能。最后,在赫兹接触理论的背景下,与天然关节软骨相比,报道了刷子功能化对摩擦学增强凝胶的力学的影响。
更新日期:2020-04-03
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