In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (e.g. Ca2+ and Mg2+) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.

中文翻译：

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自我牺牲型MOF，用于双膦酸酯类抗骨质疏松药物的超长控释。

在本文中，我们报告了基于膦酸酯MOF的药物递送系统。这些使用生物学上可接受的金属离子（例如Ca2 +和Mg2 +）和几种抗骨质疏松症的双膦酸酯类药物（依替膦酸，帕米膦酸，阿仑膦酸和neridronate）作为有机连接基。这些材料已经合成，结构表征并研究了双膦酸酯活性成分的自我牺牲释放（通过pH驱动溶解）。它们显示出可变的释放速率和最终释放％，具体取决于金属双膦酸盐材料的实际结构。它们的细胞毒性特征与活性成分相匹配。