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Higher virulence of swine H1N2 influenza viruses containing avian-origin HA and 2009 pandemic PA and NP in pigs and mice.
Archives of Virology ( IF 2.7 ) Pub Date : 2020-03-28 , DOI: 10.1007/s00705-020-04572-z
Yunyueng Jang 1, 2 , Taehyun Seo 1, 2 , Sang Heui Seo 1, 2
Affiliation  

Pigs are capable of harbouring influenza A viruses of human and avian origin in their respiratory tracts and thus act as an important intermediary host to generate novel influenza viruses with pandemic potential by genetic reassortment between the two viruses. Here, we show that two distinct H1N2 swine influenza viruses contain avian-like or classical swine-like hemagglutinins with polymerase acidic (PA) and nucleoprotein (NP) genes from 2009 pandemic H1N1 influenza viruses that were found to be circulating in Korean pigs in 2018. Swine H1N2 influenza virus containing an avian-like hemagglutinin gene had enhanced pathogenicity, causing severe interstitial pneumonia in infected pigs and mice. The mortality rate of mice infected with swine H1N2 influenza virus containing an avian-like hemagglutinin gene was higher by 100% when compared to that of mice infected with swine H1N2 influenza virus harbouring classical swine-like hemagglutinin. Further, chemokines attracting inflammatory cells were strongly induced in lung tissues of pigs and mice infected by swine H1N2 influenza virus containing an avian-like hemagglutinin gene. In conclusion, it is necessary for the well-being of humans and pigs to closely monitor swine influenza viruses containing avian-like hemagglutinin with PA and NP genes from 2009 pandemic H1N1 influenza viruses.

中文翻译:

猪和小鼠中含有禽源 HA 和 2009 年大流行 PA 和 NP 的猪 H1N2 流感病毒的更高毒力。

猪能够在其呼吸道中携带人类和禽类来源的甲型流感病毒,因此可以作为重要的中间宿主,通过两种病毒之间的基因重组产生具有大流行潜力的新型流感病毒。在这里,我们展示了两种不同的 H1N2 猪流感病毒含有类禽类或经典猪类血凝素,这些血凝素具有来自 2009 年大流行 H1N1 流感病毒的聚合酶酸性 (PA) 和核蛋白 (NP) 基因,这些病毒于 2018 年在韩国猪中传播。 . 含有类禽血凝素基因的猪 H1N2 流感病毒具有增强的致病性,在受感染的猪和小鼠中引起严重的间质性肺炎。与携带经典猪样血凝素基因的猪 H1N2 流感病毒感染小鼠相比,感染含有类禽血凝素基因的猪 H1N2 流感病毒的小鼠死亡率高出 100%。此外,在感染了含有类禽血凝素基因的猪 H1N2 流感病毒的猪和小鼠的肺组织中,强烈诱导了吸引炎症细胞的趋化因子。总之,为了人类和猪的健康,有必要密切监测含有来自 2009 年大流行 H1N1 流感病毒的具有 PA 和 NP 基因的类禽血凝素的猪流感病毒。在感染了含有类禽血凝素基因的猪 H1N2 流感病毒的猪和小鼠的肺组织中,强烈诱导了吸引炎症细胞的趋化因子。总之,为了人类和猪的健康,有必要密切监测含有来自 2009 年大流行 H1N1 流感病毒的具有 PA 和 NP 基因的类禽血凝素的猪流感病毒。在感染了含有类禽血凝素基因的猪 H1N2 流感病毒的猪和小鼠的肺组织中,强烈诱导了吸引炎症细胞的趋化因子。总之,为了人类和猪的健康,有必要密切监测含有来自 2009 年大流行 H1N1 流感病毒的具有 PA 和 NP 基因的类禽血凝素的猪流感病毒。
更新日期:2020-03-28
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