A perfect wound covering should prevent dryness of the wound and provide a favourable moist milieu at the wound interface allowing gas access but act as a barrier to the dirt and microorganisms. It is imperative to ensure early restoration of wound without scar formation at the site. Topical application of antiseptic preparation is the best for wound treatment because of its direct action. Zinc oxide nanoparticles (ZnO NPs) possess antimicrobial activity and enhance wound healing. Biocompatible polymers for inclusion of ZnO NPs can enhance the efficacy at lower doses while reducing the unwanted toxic effects. We synthesized ZnO NPs nanocomposites by impregnating the NPs in covalently attached gum acacia to the alginate exploiting the hydroxyl groups with aldehydes of glutaraldehyde, providing hydrated environment during wound application. Its topical application accelerated the full-thickness excision wound healing in rabbits. The polymers exerted synergistic effects due to their wound-healing potential. The wound-healing process was also investigated by transmission electron microscopy of regenerated tissues, collagen contents, alizared staining and histological observations to elucidate the healing mechanism compared to a commercially available ointment and negative controls. It has promising properties of biocompatibility, anti-inflammatory, cell adhesion and proliferation without any scar formation which are crucial for healing.

中文翻译：

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使用藻酸盐/金合欢基纳米复合材料的ZnO纳米颗粒的单次施用，可加速兔全层切开皮肤伤口的愈合。

理想的伤口覆盖物应防止伤口干燥，并在伤口界面处提供良好的湿润环境，允许气体进入，但可作为对污垢和微生物的屏障。必须确保伤口的早期恢复而在该部位没有疤痕形成。由于其直接作用，局部使用抗菌制剂最适合伤口治疗。氧化锌纳米颗粒（ZnO NPs）具有抗菌活性，可促进伤口愈合。包含ZnO NP的生物相容性聚合物可以在降低剂量的同时增强功效，同时减少有害的毒性作用。我们通过将戊二醛的羟基与羟基共价键合在树胶中，将NPs浸入藻酸盐中来合成ZnO NPs纳米复合材料，从而在伤口应用过程中提供水合环境。它的局部应用加速了兔全层切除伤口的愈合。聚合物由于其伤口愈合潜力而发挥了协同作用。还通过透射电子显微镜对再生组织，胶原蛋白含量，铝化染色和组织学观察进行了伤口愈合过程的研究，以阐明与市售软膏和阴性对照相比的愈合机制。它具有良好的生物相容性，抗炎性，细胞粘附性和增殖性，而不会形成任何疤痕，这对愈合至关重要。还通过透射电子显微镜对再生组织，胶原蛋白含量，铝化染色和组织学观察进行了伤口愈合过程的研究，以阐明与市售软膏和阴性对照相比的愈合机制。它具有良好的生物相容性，抗炎性，细胞粘附性和增殖性，而不会形成任何疤痕，这对愈合至关重要。还通过透射电子显微镜对再生组织，胶原蛋白含量，铝化染色和组织学观察进行了伤口愈合过程的研究，以阐明与市售软膏和阴性对照相比的愈合机制。它具有良好的生物相容性，抗炎性，细胞粘附性和增殖性，而不会形成任何疤痕，这对愈合至关重要。