Abstract Beta-tricalcium phosphate (β-TCP) has been applied in the fields of medical science owing to its osteoconductive properties which stimulate the growth of new bones. However, the material itself lacks of antibacterial properties which limits its applications. Thus, in this study antibacterial β-TCP specimens were proposed by Ag and Zn dopant. Preparation method of one-step spray pyrolysis was used with advantages of low contamination and continuous production over the sol-gel and wet chemical precipitation synthesis. The crystallographic structure, morphology and chemical composition of un-doped, Ag-doped and Ag/Zn co-doped β-TCP were characterized by X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy and transmission electron microscopy, respectively. Furthermore, the antibacterial activity against Escherichia coli was examined by colony count method. Finally, two dominant formation mechanisms were discussed and the antibacterial results indicate that the addition of Zinc nitrate precursor can enhance the activity of Ag/Zn co-doped β-TCP specimen.

中文翻译：

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喷雾热解抗菌银锌共掺杂β-磷酸三钙的制备、表征及研究

摘要 β-磷酸三钙（β-TCP）由于其骨传导特性，可刺激新骨的生长，已被应用于医学领域。然而，材料本身缺乏抗菌性能，限制了其应用。因此，在本研究中，Ag 和 Zn 掺杂剂提出了抗菌 β-TCP 样品。与溶胶-凝胶法和湿法化学沉淀合成法相比，采用一步喷雾热解法制备，具有污染小、连续生产等优点。分别通过 X 射线衍射、扫描电子显微镜、能量色散光谱和透射电子显微镜表征了未掺杂、Ag 掺杂和 Ag/Zn 共掺杂 β-TCP 的晶体结构、形貌和化学成分。此外，采用菌落计数法检测对大肠杆菌的抗菌活性。最后，讨论了两种主要的形成机制，抗菌结果表明硝酸锌前体的加入可以提高 Ag/Zn 共掺杂 β-TCP 样品的活性。