Acrylamide, an environmental pollutant, is known to occur in food substances cooked at high temperatures. Studies on various models indicate acrylamide to cause several physiological conditions such as neuro- and reproductive toxicity, and carcinogenesis. In our study, exposure of Drosophila melanogaster (Oregon K strain) to acrylamide via their diet resulted in a concentration and time-dependent mortality, while the surviving flies exhibited significant locomotor deficits, most likely due to oxidative stress-induced neuronal damage. Also, Drosophila embryos exhibited signs of developmental toxicity as evidenced by the alteration in the migration of border cells and cluster cells during the developmental stages, concomitant to modulation in expression of gurken and oskar genes. Curcumin, a known antioxidant has been widely studied for its neuroprotective effects against acrylamide; however; very few studies focus on thymoquinone for its role against food toxicant. Our research focuses on the toxicity elicited by acrylamide and the ability of the antioxidants: thymoquinone, curcumin and combination of thereof, in reversing the same.

中文翻译：

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果蝇中由丙烯酰胺暴露和使用植物化学物质改善引起的发育和行为毒性。

众所周知，丙烯酰胺是一种环境污染物，会在高温下烹饪的食物中产生。对各种模型的研究表明，丙烯酰胺会引起多种生理状况，例如神经和生殖毒性以及致癌作用。在我们的研究中，果蝇（果蝇俄勒冈州K株）通过饮食接触丙烯酰胺会导致浓度和时间依赖性死亡率，而幸存的果蝇则显示出明显的运动功能障碍，最有可能是由于氧化应激引起的神经元损伤。此外，果蝇胚胎表现出发育毒性的迹象，如在发育阶段边界细胞和簇细胞迁移的改变所证实的，伴随着古肯和奥斯卡基因表达的调节。姜黄素 众所周知，一种抗氧化剂对丙烯酰胺具有神经保护作用。然而; 很少有研究关注胸腺醌对食物中毒的作用。我们的研究集中在丙烯酰胺引起的毒性和抗氧化剂：胸腺醌，姜黄素及其组合的逆转能力上。