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Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients.
Journal of Infection ( IF 28.2 ) Pub Date : 2020-03-27 , DOI: 10.1016/j.jinf.2020.03.005
Kai Liu 1 , Ying Chen 2 , Ruzheng Lin 3 , Kunyuan Han 3
Affiliation  

BACKGROUND Due to the general susceptibility of new coronaviruses, the clinical characteristics and outcomes of elderly and young patients may be different. OBJECTIVE To analyze the clinical characteristics of elderly patients with 2019 new-type coronavirus pneumonia (COVID-19). METHODS This is a retrospective study of patients with new coronavirus pneumonia (COVID-19) who were hospitalized in Hainan Provincial People's Hospital from January 15, 2020 to February 18, 2020. Compare the clinical characteristics of elderly with Young and Middle-aged patients. RESULTS A total of 56 patients were enrolled 18 elderly patients (32.14%), and 38 young and middle-aged patients (67.86%). The most common symptoms in both groups were fever, followed by cough and sputum. Four patients in the elderly group received negative pressure ICU for mechanical ventilation, and five patients in the young and middle-aged group. One patient died in the elderly group (5.56%), and two patients died in the young and middle-aged group (5.26%). The PSI score of the elderly group was higher than that of the young and middle-aged group (P < 0.001). The proportion of patients with PSI grades IV and V was significantly higher in the elderly group than in the young and middle-aged group (P < 0.05). The proportion of multiple lobe involvement in the elderly group was higher than that in the young and middle-aged group (P < 0.001), and there was no difference in single lobe lesions between the two groups. The proportion of lymphocytes in the elderly group was significantly lower than that in the young and middle-aged group (P < 0.001), and the C-reactive protein was significantly higher in the young group (P < 0.001). The Lopinavir and Ritonavir Tablets, Chinese medicine, oxygen therapy, and mechanical ventilation were statistically different in the elderly group and the young and middle-aged group, and the P values were all <0.05. INTERPRETATION The mortality of elderly patients with COVID-19 is higher than that of young and middle-aged patients, and the proportion of patients with PSI grade IV and V is significantly higher than that of young and middle-aged patients. Elderly patients with COVID-19 are more likely to progress to severe disease.

中文翻译:

老年患者中COVID-19的临床特征:与年轻和中年患者的比较。

背景技术由于新型冠状病毒的一般易感性,老年和年轻患者的临床特征和预后可能有所不同。目的分析2019年新型冠状病毒性肺炎(COVID-19)的老年患者的临床特征。方法这是一项对2020年1月15日至2020年2月18日在海南省人民医院住院的新冠状病毒性肺炎(COVID-19)患者的回顾性研究。比较老年人和中青年患者的临床特征。结果共有56例患者入选18例老年患者(32.14%),以及38例中青年患者(67.86%)。两组中最常见的症状是发烧,然后是咳嗽和痰。老年组中有4例患者接受了负压ICU进行机械通气,而中青年组中有5例患者。老年组死亡1例(5.56%),中青年组死亡2例(5.26%)。老年人组的PSI评分高于年轻和中年组(P <0.001)。老年组PSI IV级和V级患者的比例显着高于青年和中年组(P <0.05)。老年组多叶受累的比例高于青年和中年组(P <0.001),两组之间的单叶病变无差异。老年人组的淋巴细胞比例显着低于青年和中年组(P <0.001),C反应蛋白在青年组中显着更高(P <0.001)。Lopinavir和Ritonavir片,中药,氧疗和机械通气在老年组和中青年组之间有统计学差异,P值均<0.05。解释老年COVID-19患者的死亡率高于青年和中年患者,PSI IV级和V级患者的比例显着高于青年和中年患者。患有COVID-19的老年患者更有可能发展为严重疾病。001)。Lopinavir和Ritonavir片,中药,氧疗和机械通气在老年组和中青年组之间有统计学差异,P值均<0.05。解释老年COVID-19患者的死亡率高于青年和中年患者,PSI IV级和V级患者的比例显着高于青年和中年患者。患有COVID-19的老年患者更有可能发展为严重疾病。001)。Lopinavir和Ritonavir片,中药,氧疗和机械通气在老年组和中青年组均有统计学差异,P值均<0.05。解释老年COVID-19患者的死亡率高于年轻和中年患者,PSI IV和V级患者的比例显着高于年轻和中年患者。患有COVID-19的老年患者更有可能发展为严重疾病。解释老年COVID-19患者的死亡率高于年轻和中年患者,PSI IV和V级患者的比例显着高于年轻和中年患者。患有COVID-19的老年患者更有可能发展为严重疾病。解释老年COVID-19患者的死亡率高于青年和中年患者,PSI IV级和V级患者的比例显着高于青年和中年患者。患有COVID-19的老年患者更有可能发展为严重疾病。
更新日期:2020-03-27
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