The novel Ca-Ta₂O₅ nanorods films were successfully prepared by two step hydrothermal synthesis. XRD (X-ray diffraction), SEM (scanning electron microscope), TEM (transmission electron microscopy), XPS (X-ray photoelectron spectroscopy) and AFM (atomic force microscopy) were used to analyze the phase and surface microstructure. ICP (inductively coupled plasma emission spectroscopy) was used to detect the ion precipitation concentration of the samples in normal saline, and the apatite induction ability was tested by simulated body fluid immersion experiment. Finally, the biological activity of the calcium-doped nanorods film was tested by cell experiment. The results showed that the Ta₂O₅ and Ca-Ta₂O₅ nanorods films were formed on tantalum and exhibited a nanorod structure growing along the [001] direction. The roughness and morphology of the nanorods had not been significantly affected by the doping of calcium. The Ca-Ta₂O₅ nanorods had good in vitro structural stability. Compared to Ta₂O₅ nanorods, the apatite induction ability of Ca-Ta₂O₅ nanorods film was significantly enhanced. Under the dual action of the nanorods structure and the element of Ca, the in vitro cell-culture studies clearly demonstrate that the Ca-Ta₂O₅ nanorod film was more suitable for the attachment and proliferation of MC3T3-E1 cells than the Ta substrate and Ta₂O₅ nanorod films. The Ta substrate/Ca-Ta₂O₅ nanorods film is expected to be a promising biomaterial for orthopedic applications for its high biocompatibility and bioactivity.

通过两步水热合成成功制备了新型的Ca-Ta ₂ O ₅纳米棒薄膜。使用XRD（X射线衍射），SEM（扫描电子显微镜），TEM（透射电子显微镜），XPS（X射线光电子能谱）和AFM（原子力显微镜）来分析相和表面微观结构。ICP（电感耦合等离子体发射光谱法）用于检测生理盐水中样品的离子沉淀浓度，并通过模拟体液浸没实验测试了磷灰石的诱导能力。最后，通过细胞实验测试了掺钙纳米棒膜的生物活性。结果表明，Ta ₂ O ₅和Ca-Ta ₂ O在钽上形成_5个纳米棒膜，并显示出沿[001]方向生长的纳米棒结构。钙的掺杂并未明显影响纳米棒的粗糙度和形态。Ca-Ta ₂ O ₅纳米棒具有良好的体外结构稳定性。与Ta ₂ O ₅纳米棒相比，Ca-Ta ₂ O ₅纳米棒薄膜的磷灰石诱导能力得到显着增强。在纳米棒结构和钙元素的双重作用下，体外细胞培养研究清楚地表明，Ca-Ta ₂ O ₅纳米棒膜比Ta衬底和Ta ₂ O ₅纳米棒膜更适合MC3T3-E1细胞的附着和增殖。Ta衬底/ Ca-Ta ₂ O ₅纳米棒膜由于其高的生物相容性和生物活性而有望成为骨科应用的有前途的生物材料。