当前位置: X-MOL 学术BMC Musculoskelet. Disord. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Contralateral C7 transfer to axillary and median nerves in rats with total brachial plexus avulsion
BMC Musculoskeletal Disorders ( IF 2.3 ) Pub Date : 2020-03-28 , DOI: 10.1186/s12891-020-03209-1
Yuzhou Liu , Feng Xiao , Yongqing Zhuang , Jie Lao

Contralateral cervical 7 nerve (cC7) was used to repair two recipient nerves simultaneously for patients with total brachial plexus avulsion (TBPA). To evaluate the effect of cC7 transfer to axillary and median nerves in rats with TBPA. Eighty S-D rats were divided into 4 groups randomly on average. Group A: cC7-median nerve, Group B: cC7-axillary nerve, Group C: cC7-median and axillary nerves, Group D: TBPA without repair. The evaluation tools included behavioral tests, electromyogram (EMG), measurement of cross-sectional area of muscle fiber, nerve fiber count and gene expression assay. The effective rates of EMG were 90 and 70% in Flexor Carpi Radialis (FCR) in Group A and C, while 70 and 60% in deltoid (DEL) in Group B and C, respectively. In behavioral test, the differences of effective rates between groups were not significant. The mean cross-sectional area of FCR in Group A or C was significantly larger than that in Group D. Either the number of median or axillary nerve fibers in Group A, B or C was statistically more than that in Group D. No matter for FCR or DEL, there were no significant differences in the ratios of relative expression of Muscle Atrophy F-box(MAFBOX)and Muscle RING Finger 1(MURF1)among these groups. Compared with cC7 transfer to median nerve, cC7 transfer to both median and axillary nerves did not affect median nerve recovery. The deltoid muscle also could be restored. The recovery proportion of axillary nerve was less than that of median nerve.

中文翻译:

对侧C7转移至全臂丛神经撕脱大鼠的腋窝和正中神经

对侧颈7神经(cC7)用于同时修复全臂丛神经撕脱(TBPA)患者的两条受者神经。评估cC7转移对TBPA大鼠的腋窝神经和正中神经的影响。将80只SD大鼠平均随机分为4组。A组:cC7中神经,B组:cC7中枢神经,C组:cC7中枢和腋神经,D组:TBPA,无修复。评估工具包括行为测试,肌电图(EMG),肌纤维横截面积的测量,神经纤维计数和基因表达测定。在A组和C组中,腕屈肌(FCR)的肌电图有效率分别为90%和70%,而在B组和C组,三角肌(DEL)的肌电图有效率分别为70%和60%。在行为测试中,两组之间的有效率差异不显着。A或C组的FCR平均横截面积显着大于D组。A,B或C组的中位或腋神经纤维数量在统计学上均高于D组。 FCR或DEL,两组之间的肌肉萎缩F盒(MAFBOX)和无名指1(MURF1)的相对表达比例没有显着差异。与将cC7转移至正中神经相比,将cC7转移至正中神经和腋神经均不影响正中神经的恢复。三角肌也可以恢复。腋神经的恢复比例小于正中神经。无论是FCR还是DEL,在这些组中,肌肉萎缩F-box(MAFBOX)和RING RING Finger 1(MURF1)的相对表达比率均无显着差异。与将cC7转移至正中神经相比,将cC7转移至正中神经和腋神经均不影响正中神经的恢复。三角肌也可以恢复。腋神经的恢复比例小于正中神经。无论是FCR还是DEL,在这些组中,肌肉萎缩F-box(MAFBOX)和RING RING Finger 1(MURF1)的相对表达比率均无显着差异。与将cC7转移至正中神经相比,将cC7转移至正中神经和腋神经均不影响正中神经的恢复。三角肌也可以恢复。腋神经的恢复比例小于正中神经。
更新日期:2020-03-28
down
wechat
bug