A concise enantio- and stereocontrolled synthesis of (+)-lycoperdic acid is presented. The stereochemical control is based on iminium-catalyzed Mukaiyama–Michael reaction and enamine-catalyzed organocatalytic α-chlorination steps. The amino group was introduced by azide displacement, affording the final stereochemistry of (+)-lycoperdic acid. Penultimate hydrogenation and hydrolysis afforded pure (+)-lycoperdic acid in seven steps from a known silyloxyfuran.

中文翻译：

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（+）-Lycoperdic acid的催化对映选择性全合成。

简明的对映体和立体控制合成（+）-lyperperdic酸。立体化学控制基于亚胺基催化的Mukaiyama-Michael反应和烯胺催化的有机催化α-氯化步骤。通过叠氮化物置换引入氨基，从而提供（+）-乙过二酸的最终立体化学。倒数第二次氢化和水解从已知的甲硅烷氧基呋喃分七步得到纯的（+）-乙二酸。