Due to the complexity of detection environments, field‐effect transistor (FET) sensors face the problem of fouling in practical applications. Existing antifouling strategies normally block the sensing sites and decrease the detection sensitivity. It remains a great challenge to achieve antifouling and sensitive detection. Here, a strategy is developed to use covalent organic frameworks (COFs) as the sensing interface. Owing to their unique crystalline mesoporous structure, the COFs not only encapsulate and prevent the channel from being fouled but also provide a large specific surface area modified with receptors. This approach enables the detection of 10⁻¹⁰ m Hg²⁺ within 50 ms in a ≈30 ppm poly‐(3,4‐ethylenedioxythiophene):poly‐(styrenesulfonate) solution and weak neural potential signals in complex bio‐environment, which is among the best performance for antifouling FET sensors. The COF interface enables highly sensitive and antifouling detection together with a fast response and large response range, which shows its great potential in high‐performance antifouling FET sensors.

中文翻译：

---

基于共价有机框架的防污场效应晶体管传感接口

由于检测环境的复杂性，场效应晶体管（FET）传感器在实际应用中面临结垢问题。现有的防污策略通常会阻塞感应位置并降低检测灵敏度。实现防污和灵敏检测仍然是一个巨大的挑战。在这里，开发了一种策略来使用共价有机框架（COF）作为传感界面。由于其独特的晶体介孔结构，COF不仅封装并防止通道被污染，而且还提供了被受体修饰的大比表面积。该方法可检测10 ^-10 m Hg ²⁺在约30 ppm的聚（3,4-亚乙二氧基噻吩）：聚（苯乙烯磺酸盐）溶液中在50毫秒内可在复杂的生物环境中获得弱神经电势信号，这是防污FET传感器的最佳性能之一。COF接口可实现高灵敏度和防污检测，并具有快速响应和大响应范围，这显示了其在高性能防污FET传感器中的巨大潜力。