Background

Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy.

Methods

We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Library for eligible prospective studies. The primary predictor was malaria during pregnancy defined as placental malaria, parasitemia, clinical malaria, or pregnancy-associated malaria. Primary outcomes were parasitemia or clinically defined malaria of young children. We performed meta-analyses to pool adjusted risk estimates using a random effects model.

Results

Nineteen of 2053 eligible studies met inclusion criteria for the systemic review. Eleven of these studies were quantitative and were included in the meta-analyses. The pooled adjusted odds ratio (aOR) or adjusted hazard ratio (aHR) of malaria during pregnancy for detection of parasitemia in young children were 1.94 [95% confidence interval (CI), 0.93-4.07; p=0.08] and 1.46 (95% CI, 1.07-2.00; p<0.001), respectively. The pooled aOR or aHR for clinically defined malaria in young children were 2.82 (95% CI, 1.82-4.38; p<0.001) and 1.31 (95% CI, 0.96-1.79; p=0.09), respectively.

Conclusions

Our results confirmed that malaria during pregnancy significantly increased the overall risk of malaria in young children via indeterminate mechanisms, and emphasize the urgent need to implement safe and highly effective strategies to prevent malaria during pregnancy.

中文翻译：

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妊娠期疟疾对幼儿疟疾风险的影响：系统评价和荟萃分析。

背景

我们的目标是量化怀孕期间患有疟疾的妇女的后代感染疟疾的风险。

方法

我们在 MEDLINE、EMBASE、CINAHL 和 Cochrane 图书馆中检索了符合条件的前瞻性研究。主要预测因子是妊娠期疟疾，定义为胎盘疟疾、寄生虫血症、临床疟疾或妊娠相关疟疾。主要结局是幼儿寄生虫血症或临床定义的疟疾。我们使用随机效应模型进行荟萃分析以汇集调整后的风险估计。

结果

2053 项合格研究中有 19 项符合系统评价的纳入标准。其中十一项研究是定量的，并被纳入荟萃分析中。用于检测幼儿寄生虫血症的妊娠期疟疾的汇总调整比值比 (aOR) 或调整风险比 (aHR) 为 1.94 [95% 置信区间 (CI)，0.93-4.07；95% 置信区间 (CI)，0.93-4.07；分别为 p=0.08] 和 1.46（95% CI，1.07-2.00；p<0.001）。临床定义的幼儿疟疾的汇总 aOR 或 aHR 分别为 2.82 (95% CI, 1.82-4.38; p<0.001) 和 1.31 (95% CI, 0.96-1.79; p=0.09)。

结论

我们的研究结果证实，妊娠期疟疾通过不确定机制显着增加幼儿患疟疾的总体风险，并强调迫切需要实施安全、高效的策略来预防妊娠期疟疾。