Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/I) and the binding subunits A2 and B of heat labile-enterotoxin (LTb) is immunogenic and protects against weight loss and diarrhea. These findings document the immunogenicity and pre-clinical efficacy effects of CVD 1208S-122 vaccine and suggest that further work can help elucidate relevant immune responses and ultimately its clinical efficacy in humans.

由于缺乏最佳动物模型，弗氏志贺氏菌和产肠毒素大肠杆菌的疫苗研究受到影响。我们使用了两种鼠类模型来证明一种表达产肠毒素大肠杆菌定植因子抗原-I (CFA/I) 和不耐热肠毒素 (LTb) 的结合亚基 A2 和 B 的福氏链球菌 2a 二价疫苗 (CVD 1208S-122 )具有免疫原性，可防止体重减轻和腹泻。这些发现证明了 CVD 1208S-122 疫苗的免疫原性和临床前疗效，并表明进一步的工作可以帮助阐明相关的免疫反应，并最终阐明其在人类中的临床疗效。