Data sources MEDLINE, PubMed, Scopus and Web of Science.

Study selection Two reviewers independently selected observational studies which compared caries experience between children with learning disabilities (CLD) and children with no learning disabilities (CNLD).

Data extraction and synthesis DMFT/dmft, Care Index (CI) and Restorative Index (RI) data was extracted from each study. Meta analyses were conducted on the overall data and then on the following subgroups: Down's syndrome, autism and mixed learning disabilities. An adapted Newcastle-Ottawa Scale (NOS) was used to assess bias.

Results Twenty five comparative cross sectional studies from eighteen countries were included in the review. The standardised mean difference in DMFT between CLD and CNLD was 0.43 (95% CI; 0.91 to 0.05 I² >95%) and for dmft was 0.41 (95% CI; 0.14 to 0.96 I² >95%). The only significant difference revealed by sub group analyses of the three main disability groups was lower caries experience in the permanent dentition of children with Down's syndrome (SMD = 0.73; 95% CI; 1.28 to 0.18). There was a larger difference between mean CI and mean RI for CLD than for CNLD, however, the standard deviations were large and no variance data was provided so meta-analyses could not be completed.

Conclusions Overall there was no difference in caries experience between CLD and CNLD. However, sub group analysis showed that children with Down's syndrome had lower levels of caries than CNLD but this may be due to the delayed eruption of the permanent teeth commonly seen with Down's syndrome. There was limited data suggesting that caries in permanent teeth was more commonly treated by extraction in CLD than in CNLD, however, this was based on only eight studies.

数据来源MEDLINE，PubMed，Scopus和Web of Science。

研究选择两名评论者独立选择观察性研究，比较学习障碍儿童（CLD）和非学习障碍儿童（CNLD）的龋病经历。

数据提取和合成从每项研究中提取DMFT / dmft，护理指数（CI）和恢复指数（RI）数据。对总体数据进行元分析，然后对以下子组进行元分析：唐氏综合症，自闭症和混合学习障碍。改编的纽卡斯尔-渥太华量表（NOS）用于评估偏倚。

结果该评价包括来自18个国家的25项比较性横断面研究。CLD和CNLD之间的DMFT标准化平均差为0.43（95％CI； 0.91至0.05I²> 95％），而dmft为0.41（95％CI； 0.14至0.96I²> 95％）。通过对三个主要残疾组的亚组分析揭示的唯一显着差异是唐氏综合症患儿的永久性牙列龋病经验较低（SMD = 0.73； 95％CI； 1.28至0.18）。CLD的平均CI和RI之间的差异比CNLD的差异大，但是，标准偏差较大，并且没有提供方差数据，因此无法完成荟萃分析。

结论总体而言，CLD和CNLD之间的龋齿经历没有差异。但是，亚组分析显示，唐氏综合症患儿的龋齿水平低于CNLD，但这可能是由于唐氏综合症常见的恒牙延迟萌发所致。有限的数据表明，在CLD中比在CNLD中更常通过拔牙治疗恒牙中的龋齿，但这仅基于八项研究。