Purpose

Cushing’s syndrome can negatively affect patient’s quality of life (QoL) after treatment and remission. Exposure to increased cortisol over time can result in visceral obesity, which makes this population vulnerable to cardiovascular risk factors associated with visceral obesity. Sleep disturbances are present in patients in remission from Cushing’s syndrome, impacting QoL. Moderate intensity physical activity performed 3 times a week decreases visceral obesity and improves sleep quality, therefore, engaging in physical activity after remission may improve patient’s QoL. The current study aims to explore the association between sleep quality, physical activity, and QoL in patients in remission of Cushing’s syndrome.

Methods

Patients in bio-chemical remission from Cushing’s syndrome (N = 147) were recruited through the Cushing’s Support and Research Foundation. Quality of life was assessed using the Cushing Quality of Life Questionnaire (CushingQoL), sleep was assessed with the Pittsburgh Sleep Quality Index (PSQI), and physical activity levels were assessed with the Godin-Sheppard Leisure-Time Physical Activity Questionnaire (GSLTPAQ).

Results

Sleep quality was significantly associated with both subscales of the CushingQoL (both p < .001), but physical activity was not significantly associated with either subscale. Sleep was not significantly associated with physical activity engagement in this sample.

Conclusion

Results suggest that patients in remission from Cushing’s syndrome experience sleep disturbances that are significantly associated with impaired QoL. Future research should focus on ameliorating the persisting clinical features of Cushing’s syndrome that are associated with impaired QoL after bio-chemical remission to improve QoL and expedite complete functional remission.

中文翻译：

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库欣综合征生化缓解患者的身体活动，睡眠和生活质量之间的关联。

目的

库欣综合症会对治疗和缓解后的患者生活质量（QoL）产生负面影响。随着时间的流逝，皮质醇水平升高会导致内脏肥胖，这使该人群易患与内脏肥胖相关的心血管危险因素。库欣综合征缓解的患者存在睡眠障碍，影响生活质量。每周进行3次中等强度的体育锻炼，可以减少内脏肥胖并改善睡眠质量，因此，缓解后进行体育锻炼可以改善患者的QoL。当前的研究旨在探讨库欣综合征缓解患者的睡眠质量，体力活动和生活质量之间的关系。

方法

 通过库欣支持与研究基金会招募了因库欣综合征（N = 147）而处于生化缓解状态的患者。使用库欣生活质量问卷（CushingQoL）评估生活质量，使用匹兹堡睡眠质量指数（PSQI）评估睡眠，并使用Godin-Sheppard休闲时间体育活动问卷（GSLTPAQ）评估身体活动水平。

结果

睡眠质量与CushingQoL的两个分量表均显着相关（均为p  <.001），但身体活动与两个分量表均不显着相关。在该样本中，睡眠与体育活动参与没有显着相关。

结论

结果表明，库欣综合征缓解的患者出现睡眠障碍，这与QoL受损显着相关。未来的研究应集中于改善与生化缓解后QoL受损有关的库欣综合征的持续临床特征，以改善QoL并加速完全功能缓解。