Interactions in drug solutions i.e. with another drug, antibiotic or a food supplement can alter its activity. Knowledge of their interaction in solution can help to improve the efficiency of drug in different environment in which it is being used. The interactions of fosfomycin calciumin alcohols (methanol, ethanol, n-propanol and n-butanol) were investigated using volumetric and acoustic studies. Apparent molar volume and apparent molar compressibility were obtained from experimental density and sound speed data. Hydrocarbon chain contribution of alcohols to volumetric and acoustic parameters was determined. Isentropic compressibility was calculated using speed of sound data. Obtained results were explored in terms of molecular interactions prevailing among fosfomycin calcium and alcohols. Effects of nature of solvent on molecular interactions in fosfomycin calcium was also discussed i.e. apparent molar volume increases as the size of alcohol increases with increasing alkyl chain length.

药物溶液中的相互作用，即与另一种药物，抗生素或食品补充剂的相互作用可以改变其活性。了解它们在溶液中的相互作用可以帮助提高药物在不同使用环境中的效率。使用体积和声学研究方法研究了磷霉素钙蛋白醇（甲醇，乙醇，正丙醇和正丁醇）之间的相互作用。从实验密度和声速数据获得表观摩尔体积和表观摩尔可压缩性。确定了醇对体积和声学参数的烃链贡献。使用声音数据的速度计算各向同性可压缩性。就磷霉素钙和醇之间普遍存在的分子相互作用研究了获得的结果。