The present study evaluated the exposure of children aged from one to 36 months to seven groups of mycotoxins, in the context of the infant French Total Diet Study (iTDS). Exposure was then compared to the health-based guidance values (HBGVs) for each mycotoxin. The value of the 90th percentile of exposure to nivalenol, patulin, fumonisins and zearalenone was less than 40% of the HBGV considered relevant for children. On the other hand, a risk could not be excluded for ochratoxin A and aflatoxins as exposure was close to the HBGV for ochratoxin A and the margin of exposure was much lower than the critical margin of 10,000 for aflatoxins. The HBGVs for toxins T2 and HT2, and for deoxynivalenol (DON) and its acetylated compounds were exceeded. Five percent to 10% of the children aged 5-12 months exceeded the HBGV considering the lower bound hypothesis for toxins T2 and HT2 and 7.5%-27% of the children aged 5 months and above exceeded the HBGV for DON. Consequently, the exposure of young children raises safety concerns for T2/HT2 and DON. Efforts should therefore be pursued to decrease their exposure to these molecules.

中文翻译：

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在法国婴儿总饮食研究中，饮食中真菌毒素的暴露。

在婴儿法国总饮食研究（iTDS）的背景下，本研究评估了1至36个月大的儿童接触7组霉菌毒素的情况。然后将每种真菌毒素的暴露量与基于健康的指导值（HBGV）进行比较。接受nivalenol，patulin，伏马毒素和玉米赤霉烯酮暴露的90％的值不到被认为与儿童有关的HBGV的40％。另一方面，不能排除曲霉毒素A和黄曲霉毒素的风险，因为exposure曲霉毒素A的暴露水平接近HBGV，并且暴露的余量远低于黄曲霉毒素的临界临界水平10,000。超过了毒素T2和HT2以及脱氧雪腐酚（DON）及其乙酰化化合物的HBGV。考虑到毒素T2和HT2的下限假设，5-12个月大的儿童中有5％至10％超出了HBGV，而DON超过5个月以上的儿童中有7.5％-27％超过了HBGV。因此，幼儿的接触引起对T2 / HT2和DON的安全性关注。因此，应努力减少它们对这些分子的暴露。