The cytotoxicity of three species of New Zealand (NZ) surf clam extracts was investigated in three hormonal cancer cell lines. Four extracts from each clam species were used: water, ethanol, petroleum ether (pe), and ethyl acetate (ea). The last three of these extracts significantly induced apoptosis via caspase cascades and cell cycle arrest. This was observed, for example, in the percentages of early apoptotic cells in Storm shell extracts with PC-3, MCF-7, and SiHa, with 30, 31, and 35%, respectively, at 400 μg∙ml^-1. Cells incubated for 72 h led to the induction of arrest in the S- and G2-M phases. Previous analysis showed that pe and ea extracts from NZ clams were rich in lipids, and current indications based on fractional efficacy, pointed to a lipid soluble bioactive compound. This study provided a basis for further development of NZ clam extracts for treatment, or as a supplement, for positively affecting prostate, breast, and cervical cancers.

在三种激素癌细胞系中研究了三种新西兰蛤提取物的细胞毒性。使用了每种蛤类的四种提取物：水，乙醇，石油醚（pe）和乙酸乙酯（ea）。这些提取物中的最后三个通过半胱天冬酶级联反应和细胞周期停滞显着诱导凋亡。例如，在PC-3，MCF-7和SiHa的Storm shell提取物中，早期凋亡细胞的百分比分别为400μg∙ml ^-1时分别为30％，31％和35％。温育72小时的细胞导致S-期和G2-M期的停滞诱导。先前的分析表明，新西兰蛤的pe和ea提取物富含脂质，基于适应症的当前适应症是一种脂溶性生物活性化合物。这项研究为进一步开发用于治疗或作为补充剂的NZ蛤extract提取物提供了基础，这些提取物可积极影响前列腺癌，乳腺癌和宫颈癌。