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S-Nitroso-N-acetylpenicillamine impregnated endotracheal tubes for prevention of ventilator-associated pneumonia.
Biotechnology and Bioengineering ( IF 3.8 ) Pub Date : 2020-03-25 , DOI: 10.1002/bit.27341
Katie H Homeyer 1 , Priyadarshini Singha 1 , Marcus J Goudie 1 , Hitesh Handa 1
Affiliation  

The chances of ventilator‐associated pneumonia (VAP) increases 6–20 folds when an endotracheal tube (ETT) is placed in a patient. VAP is one of the most common hospital‐acquired infections and comprises 86% of the nosocomial pneumonia cases. This study introduces the idea of nitric oxide‐releasing ETTs (NORel‐ETTs) fabricated by the incorporation of the nitric oxide (NO) donor S ‐nitroso‐N‐ acetylpenicillamine (SNAP) into commercially available ETTs via solvent swelling. The impregnation of SNAP provides NO release over a 7‐day period without altering the mechanical properties of the ETT. The NORel‐ETTs successfully reduced the bacterial infection from a commonly found pathogen in VAP, Pseudomonas aeruginosa , by 92.72 ± 0.97% when compared with the control ETTs. Overall, this study presents the incorporation of the active release of a bactericidal agent in ETTs as an efficient strategy to prevent the risk of VAP.

中文翻译:

S-Nitroso-N-acetylpenicillamine 浸渍气管内导管用于预防呼吸机相关性肺炎。

当气管插管 (ETT) 置入患者体内时,呼吸机相关性肺炎 (VAP) 的几率增加 6-20 倍。VAP 是最常见的医院获得性感染之一,占医院获得性肺炎病例的 86%。本研究介绍了通过溶剂溶胀将一氧化氮 (NO) 供体S-硝基-N-乙酰青霉胺 (SNAP) 掺入市售 ETT 来制造一氧化氮释放 ETT (NORel-ETT) 的想法。SNAP 的浸渍在 7 天内提供 NO 释放,而不会改变 ETT 的机械性能。NORel-ETTs 成功地减少了 VAP 中常见病原体铜绿假单胞菌的细菌感染,与对照 ETT 相比,减少了 92.72 ± 0.97%。总的来说,这项研究提出了在 ETT 中加入杀菌剂的主动释放作为预防 VAP 风险的有效策略。
更新日期:2020-03-25
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