Abstract A new layered coordination polymer [Cu(ox)(bib)]n (1, ox = C2O42−; bib = 1,4-bis(imidazol)butane) with helical double chains has been prepared under hydrothermal conditions and characterized by elemental analysis as well as single crystal X-ray diffraction. A green grinding method was used to produce nanorods of 1 (denoted as nano 1 hereafter) with good water dispersibility. To evaluate the protective effect of nano 1 in vivo, the coronary heart disease (CHD) rat model was constructed and nano 1 was given for treatment. The promotion of the cardiac function was measured by the left ventricular ejection fraction (LVEF) and systolic internal diameter (LVID) values. The anti-oxidative effect of nano 1 was determined by reactive oxygen species (ROS) detection. The binding interaction of 1 with the probe protein has been further examined by molecular docking simulation. Graphical Abstract

中文翻译：

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具有螺旋双链的新型Cu(II)配位聚合物：晶体结构、分子对接和通过减少氧化应激对冠心病的保护活性

摘要 在水热条件下制备了一种新型层状配位聚合物 [Cu(ox)(bib)]n (1, ox = C2O42−; bib = 1,4-bis(imidazol)butane)分析以及单晶 X 射线衍射。采用绿色研磨法制备具有良好水分散性的纳米棒1（以下记为nano 1）。为评价nano 1在体内的保护作用，构建冠心病（CHD）大鼠模型并给予nano 1治疗。通过左心室射血分数（LVEF）和收缩内径（LVID）值来衡量心脏功能的促进作用。通过活性氧（ROS）检测来确定纳米1的抗氧化作用。通过分子对接模拟进一步检查了 1 与探针蛋白的结合相互作用。图形概要