Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation,Cardiovascular Research

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Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation
Cardiovascular Research ( IF 10.8 ) Pub Date : 2020-03-26 , DOI: 10.1093/cvr/cvaa075
Quynh Nhu Dinh _{1,

2} , Antony Vinh _{1,

2} , Hyun Ah Kim _{1,

2} , Narbada Saini ₁ , Brad R S Broughton ₂ , Sophocles Chrissobolis ₃ , Henry Diep _{1,

2} , Courtney P Judkins _{1,

2} , Grant R Drummond _{1,

2} , Christopher G Sobey _{1,

2}

Affiliation

The G protein-coupled estrogen receptor 1 (GPER) may modulate some effects of aldosterone. In addition, G-1 (a GPER agonist) can lower blood pressure (BP) and promote T cell-mediated anti-inflammatory responses. This study aimed to test the effects of G-1 and G-15 (a GPER antagonist) on aldosterone-induced hypertension in mice and to examine the cellular mechanisms involved.

中文翻译：

醛固酮诱导的高血压具有性别依赖性，由 T 细胞介导，对 GPER 激活敏感

G 蛋白偶联雌激素受体 1 (GPER) 可能调节醛固酮的某些作用。此外，G-1（一种 GPER 激动剂）可以降低血压 (BP) 并促进 T 细胞介导的抗炎反应。本研究旨在测试 G-1 和 G-15（一种 GPER 拮抗剂）对醛固酮诱导的小鼠高血压的影响，并检查所涉及的细胞机制。

更新日期：2020-03-26

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