CRiSP: accurate structure prediction of disulfide-rich peptides with cystine-specific sequence alignment and machine learning.,Bioinformatics

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CRiSP: accurate structure prediction of disulfide-rich peptides with cystine-specific sequence alignment and machine learning.
Bioinformatics ( IF 5.8 ) Pub Date : 2020-03-26 , DOI: 10.1093/bioinformatics/btaa193
Zi-Lin Liu ₁ , Jing-Hao Hu _{1,

2} , Fan Jiang _{1,

3} , Yun-Dong Wu _{1,

2,

4}

Affiliation

High-throughput sequencing discovers many naturally occurring disulfide-rich peptides or cystine-rich peptides (CRPs) with diversified bioactivities. However, their structure information, which is very important to peptide drug discovery, is still very limited.

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