Background Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed. Methods (Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3–7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3–7 were related to adverse outcome in univariate and the CUS of day 3–7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II). Results Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5–4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7–4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89). Conclusion This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.

中文翻译：

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婴幼儿缺氧缺血性脑病脑超声评分系统的研制与验证

背景 缺氧缺血性脑病 (HIE) 是新生儿发病率和死亡率的重要原因。当金标准 MRI 不可行时，脑超声 (CUS) 可能会提供替代方案。在这项研究中，评估了新的 CUS 评分系统与 HIE 新生儿神经发育结果之间的关联。方法 将患有 HIE 和治疗性低温的（近）足月婴儿、出生后第 1 天和第 3-7 天的 CUS 以及可用的结果数据回顾性地包括在队列 I 中。第 1 天和第 3-7 天的 CUS 结果与不良反应相关单变量结果和第 3-7 天的 CUS 也在多变量逻辑回归分析中。阻力指数、深部灰质和白质受累的总和被纳入多变量逻辑回归分析。来自另一家医院的可比队列用于验证（队列 II）。结果 队列 I 中包括 83 名婴儿，队列 II 中包括 35 名婴儿。最终的 CUS 评分系统包含白质 (OR = 2.6, 95% CI 1.5–4.7) 和深部灰质受累 (OR = 2.7, 95% CI 1.7–4.4) 的总和。CUS 评分系统在队列 I (AUC = 0.90) 和 II (AUC = 0.89) 中表现良好。结论 这个经过验证的 CUS 评分系统与 HIE 新生儿的神经发育结果相关。