Findings from a study in mice suggest the possibility that obesity might enhance the severity of influenza infections and contribute to the virus’ continual vaccine-dodging evolution. Influenza viral strains that were experimentally passed among obese mice became more diverse and more virulent than strains that were passed among lean mice. The researchers suggest that the dialled-down interferon response seen in obese animals allows minor variants of the virus to emerge and propagate faster, resulting in greater virulence in obese mice compared with strains that circulated in only lean mice.

中文翻译：

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研究简报

在小鼠中进行的一项研究发现，肥胖可能会增加流感感染的严重性，并有助于病毒不断地躲避疫苗进化。在肥胖小鼠中实验传递的流感病毒株比在瘦小鼠中传递的病毒株更具多样性和毒性。研究人员认为，在肥胖动物身上观察到的降低的干扰素反应可使病毒的微小变体出现并传播得更快，与仅在瘦小鼠中传播的毒株相比，肥胖小鼠的毒力更高。