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An Inkjet-Printed Flexible Non-Enzymatic Lactate Sensor for Clinical Blood Plasma Test
IEEE Electron Device Letters ( IF 4.9 ) Pub Date : 2020-04-01 , DOI: 10.1109/led.2020.2973343
Yi-Syuan Huang , Kuan-Yu Chen , Yu-Ting Cheng , Chih-Kuo Lee , Hsiao-En Tsai

In this letter, we demonstrate a fully inkjet-printed electrochemical lactate sensor. The sensor is inkjet-printed on a flexible substrate, Kapton film, where silver nanoparticles (Ag NPs) are printed as conductive electrodes. The working and reference electrodes of the sensor are Ag NPs/NiO NPs/Polyurethane (PU) and Ag/AgCl(s)/PU layers respectively. The inkjet-printed PU film can not only prevent the annihilation of the Ag NPs resulting from the dissolution of Ag and the formation of AgCl in the phosphate-buffered saline (PBS) but also stabilize the lactic acid measurements by maintaining a potential variant within 2% at different lactate concentrations. The as-printed sensor exhibits a linear sensitivity of 8.86nA/mM/mm2 (R=99.6%) in the range from 0.6 to 2.2 mM. Clinical blood plasma testing results show that the trends of lactic acid change in patients measured by the sensor are the same as the ones measured using the existing detection method, colorimetric assays, in a tertiary university-affiliated hospital.

中文翻译:

用于临床血浆检测的喷墨打印柔性非酶乳酸传感器

在这封信中,我们展示了一个完全喷墨印刷的电化学乳酸传感器。该传感器通过喷墨印刷在柔​​性基板 Kapton 薄膜上,其中银纳米颗粒 (Ag NPs) 被印刷为导电电极。传感器的工作电极和参考电极分别是 Ag NPs/NiO NPs/聚氨酯 (PU) 和 Ag/AgCl(s)/PU 层。喷墨印刷的 PU 膜不仅可以防止因 Ag 溶解和 AgCl 在磷酸盐缓冲盐水 (PBS) 中形成而导致的 Ag NPs 湮灭,而且还可以通过将潜在变异保持在 2 以内来稳定乳酸测量。 % 在不同的乳酸浓度下。印刷后的传感器在 0.6 至 2.2 mM 的范围内表现出 8.86nA/mM/mm2 (R=99.6%) 的线性灵敏度。
更新日期:2020-04-01
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