This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films. Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies. The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data. Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.

中文翻译：

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伤口敷料适用复合膜中聚乙烯醇/淀粉/甘油/柠檬酸的最佳性。

这项工作解决了基于响应面方法学（RSM）设计的研究问题，从而获得了最佳的四级配方[淀粉的各种大分子浓度（St，5-10 w / w％），聚乙烯醇（PVA，5-10 w / w％），与伤口包扎膜相关的柠檬酸（CA，15-40wt％）和甘油（GI，15-40wt％）]。在此类研究中，已经考虑了27天的溶胀指数（SI），重量减轻（WL％），抗张强度（TS）和延伸百分比（％E）的适当组合。通过RSM优化获得了最优化的成分，并表现出非常好的吸水率（300.5％SI）和柔韧性（87.5％E），以及可接受的体外降解（51.4％WL）和TS（5 MPa）值，明显更好比报告的数据要多。进一步，