There is no ideal implant for mechanical strut on early-stage osteonecrosis of the femoral head (ONFH) after core decompression. In this study, a biogenic trabecular porous titanium rod with lamellar configuration was designed and fabricated using selective laser melting technique. Early-stage ONFH of sheep induced by cryo-insult were dealt with core decompression combined with rod insertion (Rod group) and core decompression alone (CD group) after X-ray evaluation was used to assess the necrotic region one months after cryo-intervention. Bone integration and ingrowth of the two groups were investigated and compared. Early-stage ONFH intervened with the rod gained better bone ingrowth than CD 3 and 6 months after the intervention, as evidenced by radiographic, micro-CT and histological evaluation. X-ray images showed compact integration between rods and peripheral bone, evidenced by no radiolucent lines encircling the rods at 3 and 6 months. Micro-CT and histological images showed that the new bone had grown into the centre of rods along the metal at 3 months, whereas the new bone grew mainly at the periphery of the decompressive channel. Micro-CT analysis show that the ratios of bone volume to total volume (BV/TV) of volume of interest (VOI) in Rod group was 890.0% and 438.1% higher than CD group at 3 (0.198 ± 0.0094 VS 0.020 ± 0.0058, p < 0.05, n = 3) and 6 (0.226 ± 0.0166 VS 0.042 ± 0.0061, p < 0.05, n = 3) months respectively. Histological analysis showed that the BV/TV of VOI in Rod group was 881.0% and 413.3% higher than CD group at 3 (0.206 ± 0.0102 VS 0.021 ± 0.0061, p < 0.05, n = 3) and 6 (0.231 ± 0.0156 VS 0.045 ± 0.0059, p < 0.05, n = 3) months respectively. The mechanical tests revealed that the maximum load of Rod group was 57.6% larger than CD group at 6 months (4505.25 ± 443.86 N VS 2858.25 ± 512.91 N, p < 0.05, n = 3). These favourable short-term results can provide insight on treatment of early-stage ONFH.

对于核心减压后股骨头的早期骨坏死（ONFH），尚无理想的机械支撑植入物。在这项研究中，使用选择性激光熔化技术设计和制造了具有片状结构的生物小梁多孔钛棒。冷冻干预后羊的早期ONFH采用X线检查评估冷冻干预后1个月的坏死区域，然后进行棒芯减压联合棒插入术（Rod组）和单纯棒芯减压术（CD组）。 。研究和比较了两组的骨整合和向内生长。放射学，显微CT和组织学评估证明，早期ONFH介入棒的骨向内生长比CD 3和6个月要好。X射线图像显示杆和周围骨骼之间紧密结合，在3和6个月时没有射线可透过的线环绕杆。显微CT和组织学图像显示，新骨在3个月时已沿金属长入棒的中心，而新骨则主要生长在减压通道的周围。Micro-CT分析显示，3组（0.198±0.0094 VS 0.020±0.0058），Rod组的骨体积与目标体积（VOI）的总体积之比（VOI）分别比CD组高890.0％和438.1％，p  <0.05，n = 3）和6（0.226±0.0166 VS 0.042±0.0061，p  <0.05，n = 3）个月。组织学分析显示，在3组（0.206±0.0102 VS 0.021±0.0061，p  <0.05，n = 3）和6组（0.231±0.0156 VS 0.045）时，Rod组的VOI的BV / TV分别比CD组高881.0％和413.3％分别为±0.0059，p  <0.05，n = 3）个月。力学测试显示，在6个月时，Rod组的最大负荷比CD组大57.6％（4505.25±443.86 N VS 2858.25±512.91 N，p  <0.05，n = 3）。这些有利的短期结果可以为早期ONFH的治疗提供见识。