A magnetic field activated drug delivery and pH-sensitive controlled drug release system based on carboxyl-modified green synthesized Fe₃O₄@SiO₂ (Fe₃O₄@SiO₂-Glu) nanoparticles was established. Doxorubicin hydrochloride (DOX), as a drug model, was adsorbed onto the Fe₃O₄@SiO₂-Glu nanoparticles' surface, where the observed drug loading capacity of 34.6 mg/g was attributed to electrostatic interaction between -COO^– on the surface of Fe₃O₄@SiO₂-Glu and -NH₃⁺ of DOX. The structure, morphology and physiochemical properties of Fe₃O₄@SiO₂-Glu were characterized via TEM, FTIR, XRD, N₂ adsorption/desorption isotherms, and Zeta potential measurements. The green synthesized Fe₃O₄@SiO₂-Glu nanoparticles exhibited multilayer architecture with a BET surface area of 79.9 m²/g and a magnetization saturation of 25.9 emu/g. Drug release experiments indicated that DOX was pH trigger released with 60.8% released within 72 h at pH 3.5. This system has important potential implications for the design of more effective and stable magnetic Fe₃O₄@SiO₂-Glu materials as drug carriers for targeted and controlled drug release.

建立了基于羧基修饰的绿色合成Fe ₃ O ₄ @SiO ₂（Fe ₃ O ₄ @SiO ₂ -Glu）纳米粒子的磁场激活药物输送和pH敏感的控释系统。作为药物模型的盐酸阿霉素（DOX）吸附在Fe ₃ O ₄ @SiO ₂ -Glu纳米颗粒的表面上，其中观察到的34.6 mg / g的载药量归因于-COO ^–在药物分子上的静电相互作用。Fe ₃ O ₄ @SiO ₂ -Glu和-NH ₃ ^+的表面DOX。通过TEM，FTIR，XRD，N ₂吸附/解吸等温线和Zeta电位测量，表征了Fe ₃ O ₄ @SiO ₂ -Glu的结构，形态和理化性质。绿色合成的Fe ₃ O ₄ @SiO ₂ -Glu纳米颗粒表现出多层结构，其BET表面积为79.9 m ² / g，磁化饱和度为25.9 emu / g。药物释放实验表明DOX是pH触发释放的，在pH 3.5的72小时内释放了60.8％。该系统对设计更有效，更稳定的磁性Fe ₃ O ₄ @SiO具有重要的潜在意义。₂ -Glu材料用作靶向和控制药物释放的药物载体。