Hippocampal place cells selectively fire when an animal traverses a particular location and are considered a neural substrate of spatial memory. Place cells were shown to change their activity patterns (remap) across different spatial contexts but to maintain their spatial tuning in a fixed familiar context. Here, we show that mouse hippocampal neurons can globally remap, forming multiple distinct representations (maps) of the same familiar environment, without any apparent changes in sensory input or behavior. Alternations between maps occurred only across separate visits to the environment, implying switching between distinct stable attractors in the hippocampal network. Importantly, the different maps were spatially informative and persistent over weeks, demonstrating that they can be reliably stored and retrieved from long-term memory. Taken together, our results suggest that a memory of a given spatial context could be associated with multiple distinct neuronal representations, rather than just one.

中文翻译：

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同一空间上下文的多个地图可以在小鼠海马中稳定地共存。

当动物横越特定位置时，海马位置细胞会选择性激发，并被认为是空间记忆的神经基础。显示了放置单元在不同的空间环境中更改其活动模式（重新映射），但在固定的熟悉环境中保持其空间调整。在这里，我们显示了小鼠海马神经元可以全局重新映射，从而形成相同熟悉环境的多个不同表示（映射），而感觉输入或行为没有任何明显变化。地图之间的交替仅在对环境的单独访问中发生，这意味着在海马网络中不同的稳定吸引子之间进行切换。重要的是，不同的地图在几周内具有丰富的空间信息并具有持久性，这表明它们可以可靠地存储并从长期记忆中检索。