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The Helicobacter pylori Cag Type IV Secretion System.
Trends in Microbiology ( IF 15.9 ) Pub Date : 2020-03-26 , DOI: 10.1016/j.tim.2020.02.004
Timothy L Cover 1 , D Borden Lacy 2 , Melanie D Ohi 3
Affiliation  

Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H. pylori Cag T4SS is substantially more complex than that of prototype T4SSs in other bacterial species. In this review, we discuss recent discoveries pertaining to the structure and function of the Cag T4SS and its role in gastric cancer pathogenesis.



中文翻译:

幽门螺杆菌 Cag IV 型分泌系统。

含有cag致病岛的幽门螺杆菌菌株在人胃中的定植是胃癌发展的危险因素。该CAG致病岛包含编码分泌效应蛋白(相关蛋白)和IV型分泌系统(CAG T4SS)的组分的基因。H. pylori Cag T4SS的分子结构比其他细菌物种中的原型 T4SS的分子结构要复杂得多。在这篇综述中,我们讨论了与 Cag T4SS 的结构和功能及其在胃癌发病机制中的作用有关的最新发现。

更新日期:2020-03-26
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