The natural durability of wood species, defined as their inherent resistance to wood‐destroying agents, is a complex phenomenon depending on many biotic and abiotic factors. Besides the presence of recalcitrant polymers, the presence of compounds with antimicrobial properties is known to be important to explain wood durability. Based on the advancement in our understanding of fungal detoxification systems, a reverse chemical ecology approach was proposed to explore wood natural durability using fungal glutathione transferases. A set of six glutathione transferases from the white‐rot Trametes versicolor were used as targets to test wood extracts from seventeen French Guiana neotropical species. Fluorescent thermal shift assays quantified interactions between fungal glutathione transferases and these extracts. From these data, a model combining this approach and wood density significantly predicts the wood natural durability of the species tested previously using long‐term soil bed tests. Overall, our findings confirm that detoxification systems could be used to explore the chemical environment encountered by wood‐decaying fungi and also wood natural durability.

中文翻译：

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一种反向化学生态方法，用于探索木材的天然耐久性。

木材物种的自然耐久性被定义为对木材破坏剂的固有抵抗力，这是一个复杂的现象，取决于许多生物和非生物因素。除了存在顽强的聚合物外，已知具有抗菌特性的化合物的存在对于解释木材的耐久性也很重要。基于我们对真菌排毒系统的理解的进步，提出了一种反向化学生态学方法，以利用真菌谷胱甘肽转移酶探索木材的天然耐久性。一组来自白色腐烂的Trametes versicolor的六个谷胱甘肽转移酶用作测试来自法属圭亚那17个新热带物种的木材提取物的目标。荧光热移分析定量了真菌谷胱甘肽转移酶和这些提取物之间的相互作用。根据这些数据，将这种方法与木材密度相结合的模型可以显着预测先前使用长期土壤床试验所测物种的木材自然耐久性。总体而言，我们的发现证实了排毒系统可用于探索木材腐烂真菌遇到的化学环境以及木材的天然耐久性。