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Time-Dependent Cytotoxic Properties of Terpyridine-Based Copper Complexes.
ChemBioChem ( IF 3.2 ) Pub Date : 2020-03-24 , DOI: 10.1002/cbic.202000154
Jordi Grau 1 , Amparo Caubet 1 , Olivier Roubeau 2 , David Montpeyó 3 , Julia Lorenzo 3 , Patrick Gamez 1, 4, 5
Affiliation  

Some things take time: How terpyridine‐based copper complexes inhibit cancer‐cell growth depends on the functional group para to the central pyridine ring. With naphthalen‐2‐yl, the activity after 24 h of incubation with cell lines is higher than that of cisplatin. With chlorine, the complexes are still almost inactive after 24 h, but their cytotoxicity increases dramatically after 72 h.
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中文翻译:

叔丁基吡啶基铜配合物的时间依赖性细胞毒性。

一些事情需要时间:基于三联吡啶铜络合物如何抑制癌症细胞生长依赖于官能团对位于中心吡啶环。使用萘-2-基,与细胞系孵育24小时后的活性高于顺铂。在使用氯的情况下,复合物在24小时后仍几乎没有活性,但在72小时后其细胞毒性急剧增加。
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更新日期:2020-03-24
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