Despite proactive measures to prevent raccoon rabies entering Canada from the United States, several incursions of this disease have occurred. The largest outbreak, first reported in December 2015 in the city of Hamilton, Ontario, has resulted in the reporting of 449 animal cases as of December 31, 2018. Initial phylogenetic studies on the index case suggested that this outbreak was not due to local cross-border spread from the Niagara region of the United States where raccoon rabies has persisted for several years. Phylogenetic analysis of whole genome sequences of a viral collection from the Hamilton area and several US states indicates that a long-distance translocation of a diseased animal from southeastern New York State was responsible for this incursion. The role of the skunk as a potential secondary host supporting persistence and / or spread of the virus is also examined.

中文翻译：

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在加拿大安大略省汉密尔顿市，一次长距离易位引发了浣熊狂犬病的暴发。

尽管采取了积极的措施来防止浣熊狂犬病从美国进入加拿大，但还是发生了几次这种疾病的入侵。最大的疫情首次报告于2015年12月，位于安大略省的汉密尔顿市，截至2018年12月31日，共报告了449例动物病例。对该指数病例的初步系统发育研究表明，该疫情不是由于当地的交叉边界从美国的尼亚加拉地区蔓延，那里的浣熊狂犬病持续了数年。对来自汉密尔顿地区和美国多个州的病毒收藏的全基因组序列进行系统进化分析，表明这种入侵是造成来自纽约州东南部的患病动物的远距离转移。