Despite its important biological role, the evolution of recombination rates remains relatively poorly characterized. This owes, in part, to the lack of high-quality genomic resources to address this question across diverse species. Humans and our closest evolutionary relatives, anthropoid apes, have remained a major focus of large-scale sequencing efforts, and thus recombination rate variation has been comparatively well studied in this group—with earlier work revealing a conservation at the broad- but not the fine-scale. However, in order to better understand the nature of this variation, and the time scales on which substantial modifications occur, it is necessary to take a broader phylogenetic perspective. I here present the first fine-scale genetic map for vervet monkeys based on whole-genome population genetic data from ten individuals and perform a series of comparative analyses with the great apes. The results reveal a number of striking features. First, owing to strong positive correlations with diversity and weak negative correlations with divergence, analyses suggest a dominant role for purifying and background selection in shaping patterns of variation in this species. Second, results support a generally reduced broad-scale recombination rate compared with the great apes, as well as a narrower fraction of the genome in which the majority of recombination events are observed to occur. Taken together, this data set highlights the great necessity of future research to identify genomic features and quantify evolutionary processes that are driving these rate changes across primates.

中文翻译：

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黑长尾猴的精细比例遗传图谱。

尽管其具有重要的生物学作用，但重组速率的变化仍然相对较差。这在一定程度上是由于缺乏高质量的基因组资源来解决跨物种的这一问题。人类和我们最亲近的进化亲戚（类人猿）仍然是大规模测序工作的主要重点，因此，在这一组中对重组率的变化进行了比较充分的研究-早期的研究揭示了广泛的保守性，但并非如此。 -规模。但是，为了更好地理解这种变异的性质以及发生实质性修饰的时间范围，有必要采取更广阔的系统发生学视角。我在这里展示了第一只基于10个个体的全基因组种群遗传数据的黑长尾猴的精细遗传图谱，并对大猿进行了一系列比较分析。结果揭示了许多惊人的特征。首先，由于与物种的强正相关和与多样性的弱负相关，分析表明，提纯和背景选择在该物种变异形成中起主导作用。第二，与大猿相比，结果支持普遍降低的大规模重组率，并且其中观察到大多数重组事件发生的基因组片段也较小。在一起