Switching to a Second Thiopurine in Adult and Elderly Patients With Inflammatory Bowel Disease: A Nationwide Study From the ENEIDA Registry.,Journal of Crohn's and Colitis

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Switching to a Second Thiopurine in Adult and Elderly Patients With Inflammatory Bowel Disease: A Nationwide Study From the ENEIDA Registry.
Journal of Crohn's and Colitis ( IF 8 ) Pub Date : 2020-03-23 , DOI: 10.1093/ecco-jcc/jjaa055
Margalida Calafat _{1,

2} , Míriam Mañosa _{1,

2,

3} , Francisco Mesonero ₄ , Jordi Guardiola ₅ , Miguel Mínguez ₆ , Pilar Nos _{3,

7} , Isabel Vera ₈ , Carlos Taxonera ₉ , Eva Iglesias ₁₀ , Elena Ricart _{3,

11} , Javier P Gisbert _{3,

12} , Xavier Calvet _{3,

13} , Santiago García-López ₁₄ , David Monfort ₁₅ , José Lázaro Pérez Calle ₁₆ , Sabino Riestra ₁₇ , Fernando Gomollón _{3,

18} , Esther Garcia-Planella ₁₉ , Fernando Bermejo ₂₀ , Vicent Hernández ₂₁ , María Dolores Martín-Arranz ₂₂ , Ana Gutiérrez _{3,

23} , Paola Torres ₁ , Fiorella Cañete _{1,

2,

3} , Eugeni Domènech _{1,

2,

3} ,

Affiliation

Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
Centro de Investigación Biomédica en Red sobre enfermedades Hepáticas y Digestivas CIIBEREHD, Spain.
Hospital Universitario Ramón y Cajal, Madrid, Spain.
Hospital Universitari de Bellvitge, IDIBELL, [L'Hospitalet del Llobregat] Universitat de Barcelona, Barcelona, Spain.
Hospital Clínico de Valencia, Universitat de València, Valencia, Spain.
Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
Hospital Clínico San Carlos, Madrid, Spain.
Hospital Reina Sofía, Córdoba, Spain.
Hospital Clínic, IDIBAPS, Barcelona, Spain.
Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa [IIS-IP], Universidad Autónoma de Madrid, Madrid, Spain.
Hospital Parc Taulí, Sabadell, Spain.
Hospital Universitario Miguel Servet, Zaragoza, Spain.
Consorci Sanitari de Terrassa, Terrassa, Spain.
Hospital Universitario Fundación de Alcorcón, Alcorcón, Spain.
Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias [ISPA], Oviedo, Spain.
Hospital Clínico Lozano Blesa, IIS Aragón, Zaragoza, Spain.
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Hospital Universitario Fuenlabrada [Fuenlabrada] and Instituto de Investigación Sanitaria Hospital La Paz [IdiPAZ], Spain.
Complexo Hospitalario Universitario de Vigo, Vigo and Gastrointestinal Diseases Research Group, Galicia Sur Health Research Institute [IIS Galicia Sur]. SERGAS-UVIGO, Spain.
Hospital Universitario La Paz, Madrid, Spain.
Hospital General Universitario de Alicante, Alicante, Spain.

Although commonly used in inflammatory bowel disease [IBD], thiopurines frequently cause intolerance, and switching to a second thiopurine has only been reported in some small series. Ours aims in this study were to evaluate the safety of switching to a second thiopurine in a large cohort, and to assess the impact of age on tolerance.

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