Methotrexate is commonly used in combination with biologic DMARDs in the treatment of rheumatoid arthritis on the basis that the combined therapy has synergistic benefits. New data challenge this concept in the treatment of older adults and highlight the uncertainty of the mode of action of methotrexate in this population.

中文翻译：

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甲氨蝶呤是否可以改善老年RA患者的TNF抑制剂药物生存率？

甲氨蝶呤通常与生物DMARD联合用于类风湿关节炎的治疗，因为联合治疗具有协同作用。新数据挑战了老年人的治疗方法，并突显了甲氨蝶呤在这一人群中的作用方式的不确定性。