Genomic alterations are well-described in Barrett oesophagus and its sequela, oesophageal adenocarcinoma, but epigenomic events have not been so widely investigated. In a new study, Jammula et al. analysed the DNA methylation profiles of Barrett oesophagus, oesophageal adenocarcinoma and control tissues. Four molecular subtypes were identified, revealing four distinct epigenomic classes and potential therapeutic targets.

中文翻译：

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巴雷特瘤形成的分子表观基因组亚型。

在Barrett食管及其后遗症食管腺癌中已充分描述了基因组改变，但尚未对基因组事件进行如此广泛的研究。在一项新研究中，Jammula等人。分析了Barrett食管，食道腺癌和对照组织的DNA甲基化谱。确定了四个分子亚型，揭示了四个不同的表观基因组类别和潜在的治疗靶标。