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Adherence to the WCRF/AICR 2018 recommendations for cancer prevention and risk of cancer: prospective cohort studies of men and women.
British Journal of Cancer ( IF 8.8 ) Pub Date : 2020-03-25 , DOI: 10.1038/s41416-020-0806-x
Joanna Kaluza 1, 2 , Holly R Harris 3, 4 , Niclas Håkansson 1 , Alicja Wolk 1, 5
Affiliation  

BACKGROUND In 2018, the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) issued revised recommendations for cancer prevention. We examined the relation between adherence to these recommendations and risk of total cancer in two population-based Swedish prospective cohorts (29,451 men and 25,349 women). METHODS Standardized-WCRF/AICR 2018 and simplified-WCRF/AICR 2018 adherence scores were constructed based on the WCRF/AICR recommendations for body weight, physical activity, diet, alcohol consumption and dietary supplement use. Data were collected using a self-administered questionnaire. RESULTS During the 15.4 years of follow-up, 12,693 incident cancers were ascertained. The multivariable HR between extreme categories of the Standardized-WCRF/AICR 2018 score (4.1-7 vs. 0-2) was 0.88 (95% CI = 0.82-0.95) and for the Simplified score (5-8 vs. 0-2) was 0.85 (95% CI = 0.80-0.90); each 1-score increment in recommendation adherence was associated with 3% (95% CI = 1-5%) and 4% (95% CI = 2-5%) decreased risk, respectively. Based on the Simplified scoring, most participants (>90%) did not meet WCRF/AICR 2018 recommendations regarding consumption of plant foods, limited consumption of red/processed meat and 'fast food'/processed food, and <50% of participants met the weight and physical activity recommendations. CONCLUSIONS Adherence to the 2018WCRF/AICR recommendations substantially reduced the risk of total cancer. Given that many people do not meet the recommendations, there is a great potential for cancer prevention.

中文翻译:

遵守WCRF / AICR 2018关于癌症预防和癌症风险的建议:男女前瞻性队列研究。

背景技术2018年,世界癌症研究基金会/美国癌症研究所(WCRF / AICR)发布了有关癌症预防的修订建议。我们在两个以人群为基础的瑞典前瞻性队列(29,451名男性和25,349名女性)中研究了遵守这些建议与总癌症风险之间的关系。方法根据体重,体力活动,饮食,饮酒和饮食补充剂使用的WCRF / AICR建议建立标准化的WCRF / AICR 2018和简化的WCRF / AICR 2018坚持评分。使用自我管理的问卷收集数据。结果在15.4年的随访中,确定了12,693例癌症。标准化WCRF / AICR 2018得分的极端类别之间的多变量HR(4.1-7对0-2)为0.88(95%CI = 0.82-0)。95)和简化分数(5-8 vs. 0-2)为0.85(95%CI = 0.80-0.90);推荐坚持率每提高1分,就会分别降低3%(95%CI = 1-5%)和4%(95%CI = 2-5%)。根据简化评分,大多数参与者(> 90%)不符合WCRF / AICR 2018关于植物性食物的消费,红色/加工肉和'快餐'/加工食物的有限消费的建议,并且满足以下条件的参与者不到50%体重和体育锻炼建议。结论坚持2018WCRF / AICR建议可大大降低罹患总癌症的风险。鉴于许多人不符合建议,因此预防癌症的潜力很大。推荐坚持率每提高1分,就会分别使风险降低3%(95%CI = 1-5%)和4%(95%CI = 2-5%)。根据简化评分,大多数参与者(> 90%)不符合WCRF / AICR 2018关于植物性食品的消费,红色/加工肉和'快餐'/加工食品的消费限制的建议,并且满足以下条件的参与者不到50%体重和体育锻炼建议。结论坚持2018WCRF / AICR建议可大大降低罹患总癌症的风险。鉴于许多人不符合建议,因此预防癌症的潜力很大。推荐坚持率每提高1分,就会分别使风险降低3%(95%CI = 1-5%)和4%(95%CI = 2-5%)。根据简化评分,大多数参与者(> 90%)不符合WCRF / AICR 2018关于植物性食物的消费,红色/加工肉和'快餐'/加工食物的有限消费的建议,并且满足以下条件的参与者不到50%体重和体育锻炼建议。结论坚持2018WCRF / AICR建议可大大降低罹患总癌症的风险。鉴于许多人不符合建议,因此预防癌症的潜力很大。90%)不符合WCRF / AICR 2018关于食用植物性食物,红色/加工肉和'快餐'/加工食物的限量建议,并且<50%的参与者达到了体重和体育锻炼的建议。结论坚持2018WCRF / AICR建议可大大降低罹患总癌症的风险。鉴于许多人不符合建议,因此预防癌症的潜力很大。90%)不符合WCRF / AICR 2018关于食用植物性食物,红色/加工肉和'快餐'/加工食物的限量建议,并且<50%的参与者达到了体重和体育锻炼的建议。结论坚持2018WCRF / AICR建议可大大降低罹患总癌症的风险。鉴于许多人不符合建议,因此预防癌症的潜力很大。
更新日期:2020-04-24
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