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A Modified Vaccine against Smallpox
The New England Journal of Medicine ( IF 70.670 ) Pub Date : 2020-03-26 , DOI: 10.1056/nejmc2001156


This article has no abstract; the first 100 words appear below. To the Editor: The trial of modified vaccinia Ankara (MVA) reported by Pittman et al. (Nov. 14 issue)1 was underpowered to detect one of the most serious but underrecognized complications of the established vaccines ACAM2000 and Dryvax — myopericarditis (myocarditis and pericarditis). Studies have shown an incidence of approximately 1 case of clinical myopericarditis in 250 persons who have received one of these two vaccines.2 The trial conducted by Pittman et al., which enrolled 220 participants in the MVA group, probably would have failed to detect a similar incidence of cardiac events. Furthermore, the symptoms of myopericarditis can be subtle . . .
更新日期:2020-03-26

 

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