Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T cells, and most studies have focused on the participation of T cells in the pathogenesis of this disease. Here we investigated the contribution of mononuclear phagocytes in the immunopathology observed in psoriatic patients. Significant increases in the levels of TNF, IL-1β, CXCL9, as well as the soluble forms of CD14 and CD163, were observed within the lesions of psoriatic patients compared to skin biopsies obtained from healthy individuals. Moreover, we found an association between the levels of CCL2, a monocyte attractant chemokine, and disease severity. In conclusion, our findings suggest a potential role for mononuclear phagocytes in the pathogenesis of psoriasis.

牛皮癣是一种慢性炎症性疾病，会影响皮肤和关节。该病的发病机制与遗传，环境和免疫学因素有关，尤其是不平衡的T细胞活化和不正确的角质形成细胞分化。银屑病病灶浸润由单核细胞和T细胞组成，并且大多数研究集中在T细胞参与该疾病的发病机理中。在这里，我们调查了单核吞噬细胞在银屑病患者中观察到的免疫病理学中的作用。与从健康个体获得的皮肤活检相比，在银屑病患者的病变内观察到了TNF，IL-1β，CXCL9以及可溶性形式的CD14和CD163的水平显着增加。此外，我们发现CCL2的水平之间存在关联，单核细胞引诱趋化因子，以及疾病的严重程度。总之，我们的发现提示单核吞噬细胞在牛皮癣发病机理中的潜在作用。